4-FLUORO-3,5-DIMETHYLANILINE

Base Information

• Chemical Name: 4-FLUORO-3,5-DIMETHYLANILINE
• CAS No.: 1840-27-3
• Molecular Formula: C8H10FN
• Molecular Weight: 139.173
• Hs Code.: 2921430090
• Mol file: 1840-27-3.mol

Synonyms:3,5-Dimethyl-4-fluoroaniline;4-fluoro-3,5-dimethylphenylamine;4-Fluor-3,5-dimethyl-anilin;4-Fluoro-3,5-dimethylbenzenamine;4-fluoranyl-3,5-dimethyl-aniline;4-Fluoro-3,5-xylidine;

Chemical Property of 4-FLUORO-3,5-DIMETHYLANILINE

Chemical Property:

• Melting Point: 30-32℃
• Boiling Point: 225.6±35.0℃ (760 Torr)
• PKA: 4.90±0.10(Predicted)
• Flash Point: 103.5±12.5℃
• PSA: 26.02000
• Density: 1.083±0.06 g/cm3 (20 oC 760 Torr)
• LogP: 2.60590
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Sparingly soluble in water 0.71 g/L @ 25°C.

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Fluoro-3,5-dimethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Fluoro-3,5-dimethylaniline is used in the novel synthesis of fluoroaromatics.

Technology Process of 4-FLUORO-3,5-DIMETHYLANILINE

There total 4 articles about 4-FLUORO-3,5-DIMETHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

3,5-dimethyl-4-fluoro-1-bromobenzene (99725-44-7) → 4-fluoro-3,5-dimethyl-benzenamine (1840-27-3)

Guidance literature:

3,5-dimethyl-4-fluoro-1-bromobenzene; With magnesium; In tetrahydrofuran; Inert atmosphere;

With C₁₀H₁₇NO; In tetrahydrofuran; toluene; at -45 ℃; for 2h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; toluene; Inert atmosphere;

DOI:10.1038/nchem.2672

Reference yield: 69.0%

→ 4-fluoro-3,5-dimethyl-benzenamine (1840-27-3)

Guidance literature:

With magnesium; ethylene dibromide; In tetrahydrofuran; Inert atmosphere;

With C₁₀H₁₇NO; In tetrahydrofuran; toluene; at -45 ℃; for 2h; Inert atmosphere;

Reference yield:

2-fluoro-1,3-dimethyl-5-nitrobenzene (1736-85-2) → 4-fluoro-3,5-dimethyl-benzenamine (1840-27-3)

Guidance literature:

With iron; ammonium chloride;

upstream raw materials:

2-fluoro-1,3-dimethyl-5-nitrobenzene

2-fluoro-m-xylene

3,5-dimethyl-4-fluoro-1-bromobenzene

Downstream raw materials:

C₁₈H₂₁FN₂O₃S

N-(2-hydroxyethyl)-3,5-dimethyl-4-fluoroaniline

Refernces

• 1、 -. "AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS". Paragraph 0098; 0134; 0135; 0180. . Retrieved 2018/03/25.
• 2、 -. "Preparation of fluorinated anilines". . . Retrieved 2008/06/13.