Fragransin A2

Base Information

• Chemical Name: Fragransin A2
• CAS No.: 112652-46-7
• Molecular Formula: C20H24 O5
• Molecular Weight: 344.408
• Mol file: 112652-46-7.mol

Synonyms:Phenol,4,4'-(tetrahydro-3,4-dimethyl-2,5-furandiyl)bis[2-methoxy-, [2R-(2a,3b,4a,5b)]-; (+)-Fragransin A2;Fragransin A2

Chemical Property of Fragransin A2

Chemical Property:

• Melting Point: 198-200 °C
• Boiling Point: 509.7±50.0 °C(Predicted)
• PKA: 9.61±0.35(Predicted)
• PSA: 68.15000
• Density: 1.175±0.06 g/cm3(Predicted)
• LogP: 4.19980

Purity/Quality:

98% ^*data from raw suppliers

FragransinA2 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Fragransin A2

There total 38 articles about Fragransin A2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

C27H30O5 (915158-87-1) → (+)-fragransin A2 (112652-46-7)

Guidance literature:

With palladium dihydroxide; hydrogen; In ethyl acetate;

DOI:10.1055/s-2007-968019

Reference yield: 12.8%

(-)-Galbelgin (10569-12-7) → (+)-fragransin A2 (50393-85-6,50544-07-5,74683-16-2,76261-19-3,83198-63-4,112652-46-7,114422-21-8,126643-11-6,128524-98-1,131829-51-1,143062-67-3)

Guidance literature:

With Aspergillus niger; In dimethyl sulfoxide; at 28 ℃; for 36h;

DOI:10.1016/0031-9422(96)00222-1

Reference yield: 5.3%

galgravin (528-63-2) → nectandrin-B (50393-85-6,50544-07-5,74683-16-2,76261-19-3,83198-63-4,112652-46-7,114422-21-8,126643-11-6,128524-98-1,131829-51-1,143062-67-3)

Guidance literature:

With Aspergillus niger; In dimethyl sulfoxide; at 28 ℃; for 48h;

DOI:10.1016/0031-9422(96)00222-1

upstream raw materials:

galgravin

(7R,7′S,8S,8′R)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

(-)-Galbelgin

(7S,7′S,8R,8′R)-4,4′-dibenzyloxy-3,3′-dimethoxy-7,7′-epoxylignane-9,9′-diol

Downstream raw materials:

galbelgin

1,4-bis(3,4-dimethoxyphenyl)-2,3-dimethylbutane

(+/-)-trans-4-(3,4-dimethoxyphenyl)-3,4-dihydro-6,7-dimethoxy-2,3-dimethylnaphthalene

veraguensin

Refernces

• 1、 Nishiwaki, Hisashi,Nakayama, Kumiko,Shuto, Yoshihiro,Yamauchi, Satoshi. "Synthesis of all stereoisomers of 3,3-Dimethoxy-7,7-epoxylignane-4,4-diol and their plant growth inhibitory activity". . p. 651 - 659. Retrieved 2015/04/22.
• 2、 -. "MANASSANTIN COMPOUNDS AND METHODS OF MAKING AND USING SAME". Page/Page column 42-43. . Retrieved 2010/07/10.