Ethyl 3,4-diaminobenzoate

Base Information

• Chemical Name: Ethyl 3,4-diaminobenzoate
• CAS No.: 37466-90-3
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Hs Code.: 29224985
• Mol file: 37466-90-3.mol

Synonyms:3,4-Diaminobenzoicacid ethyl ester;4-Carbethoxy-o-phenylenediamine;Ethyl 3,4-diaminobenzoate;

Chemical Property of Ethyl 3,4-diaminobenzoate

Chemical Property:

• Appearance/Colour: beige fluffy powder
• Vapor Pressure: 4.63E-06mmHg at 25°C
• Melting Point: 108-113 °C
• Refractive Index: 1.605
• Boiling Point: 382.7 °C at 760 mmHg
• Flash Point: 216.1 °C
• PSA: 78.34000
• Density: 1.214g/cm³
• LogP: 2.19010
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 3,4-Diaminobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3,4-diaminobenzoate

There total 9 articles about Ethyl 3,4-diaminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.4%

ethanol (64-17-5) + 3,4-diaminobenzoic acid (619-05-6) → ethyl 3,4-diaminobenzoate (37466-90-3)

Guidance literature:

ethanol; 3,4-diaminobenzoic acid; With sulfuric acid; for 3h; Reflux;

With sodium carbonate; In water; pH=7; Cooling with ice;

Reference yield: 90.4%

ethanol (64-17-5) + sulfuric acid (7664-93-9) + 3,4-diaminobenzoic acid (619-05-6) → ethyl 3,4-diaminobenzoate (37466-90-3)

Guidance literature:

Reference yield:

ethyl 4-amino-3-nitrobenzoate (76918-64-4) → ethyl 3,4-diaminobenzoate (37466-90-3)

Guidance literature:

With hydrogenchloride; tin(ll) chloride;

upstream raw materials:

ethyl 4-amino-3-nitrobenzoate

ethanol

3,4-diaminobenzoic acid

2-nitro-5-ethoxycarbonylaniline

Downstream raw materials:

Chinoxalin-6-carbonsaeure-ethylester

ethyl 2-methyl-1H-benzimidazole-5-carboxylate

benzo[1,2,5]thiadiazole-5-carboxylic acid ethyl ester

2-(4-chloro-3-methyl-phenoxy)-2-oxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphole-5-carboxylic acid ethyl ester

Refernces

• 1、 Katsuyama, Isamu,Kubo, Masanori. "The First Synthesis of Protected 5-Hydroxymethyl-2-cyanomethylbenzimidazole". . p. 2491 - 2497. Retrieved 2007.
• 2、 Yeong, Keng Yoon,Chia, Tze Shyang,Quah, Ching Kheng,Tan, Soo Choon. "Synthesis and Crystal Structures of Ethyl 2-(4-Methoxyphenyl)-1H-benzo[d]imidazole-5-carboxylate Dihydrate and Its Building Block 4-Fluoro-3-nitrobenzoic Acid". . p. 170 - 176. Retrieved 2018/08/21.
• 3、 -. "COMPOUND AND METHOD FOR INHIBITING SIRTUIN ACTIVITIES". Page/Page column 9; 10. . Retrieved 2017/01/26.