PHT-DL-VAL-OH

Base Information

• Chemical Name: PHT-DL-VAL-OH
• CAS No.: 5115-65-1
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.251
• Hs Code.: 2925190090
• Mol file: 5115-65-1.mol

Synonyms:2-Isoindolineaceticacid, a-isopropyl-1,3-dioxo-, DL- (8CI);2H-Isoindole-2-acetic acid, 1,3-dihydro-a-(1-methylethyl)-1,3-dioxo-, (?à)-; 1,3-Dihydro-1,3-dioxo-a-isopropyl-2H-isoindole-2-aceticacid; 2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-methylbutanoic acid;3-Methyl-2-(phthalimido)butanoic acid; NSC 27515

Chemical Property of PHT-DL-VAL-OH

Chemical Property:

• PSA: 74.68000
• Density: 1.353
• LogP: 1.32970

Purity/Quality:

98%Min ^*data from raw suppliers

Phthaloyl-DL-Valine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(1,3-Dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-methylbutanoic acid is used as a reactant in the preparation of p-?spiro diaminodioxaphosphonium barfates.

Technology Process of PHT-DL-VAL-OH

There total 6 articles about PHT-DL-VAL-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

phthalic anhydride (85-44-9) + D-Val-OH (640-68-6,25609-85-2,7004-03-7,921-10-8) → (R)-N-phthaloylvaline (5115-65-1,6306-53-2,6306-54-3,19506-85-5)

Guidance literature:

With triethylamine; In toluene; Heating;

DOI:10.1016/j.tet.2005.07.049

Reference yield: 78.0%

phthalic anhydride (85-44-9) + D,L-valine (516-06-3,25609-85-2,7004-03-7,921-10-8) → N-phthaloyl-DL-valine (5115-65-1,6306-53-2,6306-54-3,19506-85-5)

Guidance literature:

at 100 ℃; for 1h;

Reference yield:

C19H29NO4Si2 (1242459-41-1) → (R)-N-phthaloylvaline (5115-65-1,6306-53-2,6306-54-3,19506-85-5) + N-phthaloyl L-valine (6306-54-3)

Guidance literature:

With 2,6-di-tert-butyl-pyridine; 2.6-dimethylphenol; C₃₂H₁₂BF₂₄^(1-)*C₄₄H₃₀N₂O₂P⁽¹⁺⁾; In toluene; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja105945z

upstream raw materials:

phthalic anhydride

D-Val-OH

C₁₉H₂₉NO₄Si₂

N-phthaloyl-DL-valine

Downstream raw materials:

methyl 3-methyl-2-phthalimidobutyrate

L-valine

Refernces

• 1、 Bauer, Adriano,Borsos, Eszter,Maulide, Nuno. "A Novel Class of 7-Membered Heterocyclic Compounds". supporting information. p. 3971 - 3974. Retrieved 2020/05/25.
• 2、 Samir, Ali H.,Saeed, Ruwaidah S.,Matty, Fadhel S.. "Synthesis and study of modified polyvinyl alcohol containing amino acid moieties as anticancer agent". . p. 286 - 294. Retrieved 2018/03/21.