1H-Pyrrole-2,5-dione, 1-dodecyl-

Base Information

• Chemical Name: 1H-Pyrrole-2,5-dione, 1-dodecyl-
• CAS No.: 17616-03-4
• Molecular Formula: C16H27NO2
• Molecular Weight: 265.396
• Hs Code.: 2925190090
• DSSTox Substance ID: DTXSID7066223
• Nikkaji Number: J171.256J
• Wikidata: Q81992813
• Mol file: 17616-03-4.mol

Synonyms:17616-03-4;N-Laurylmaleimide;1-dodecylpyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-dodecyl-;1-DODECYL-PYRROLE-2,5-DIONE;N-dodecyl maleimide;1-Dodecyl-1H-pyrrole-2,5-dione;AI3-02973;n-dodecyl-maleinimid;N-dodecylmaleimide;N-Dodecylmaleinimide;N-n-dodecylmaleimide;n-dodecyl maleinimide;SCHEMBL36400;DTXSID7066223;MFCD00080501;BS-51163;FT-0769314;1-dodecyl-2,5-dihydro-1H-pyrrole-2,5-dione;F71356

Chemical Property of 1H-Pyrrole-2,5-dione, 1-dodecyl-

Chemical Property:

• Vapor Pressure: 9.95E-06mmHg at 25°C
• Refractive Index: 1.488
• Boiling Point: 371.9 °C at 760 mmHg
• Flash Point: 142 °C
• PSA: 37.38000
• Density: 0.987 g/cm³
• LogP: 3.77020
• XLogP3: 6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 11
• Exact Mass: 265.204179104
• Heavy Atom Count: 19
• Complexity: 292

Purity/Quality:

99% ^*data from raw suppliers

1-DODECYL-PYRROLE-2,5-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-27-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCN1C(=O)C=CC1=O

Technology Process of 1H-Pyrrole-2,5-dione, 1-dodecyl-

There total 8 articles about 1H-Pyrrole-2,5-dione, 1-dodecyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

maleic anhydride (108-31-6) + n-Dodecylamine (124-22-1) → n-dodecylmaleimide (17616-03-4)

Guidance literature:

maleic anhydride; n-Dodecylamine; In benzene; at 30 ℃; for 1h;

With 1,1,1,3,3,3-hexamethyl-disilazane; zinc dibromide; In benzene; for 2h; Reflux;

DOI:10.1021/ol9016723

Reference yield: 81.0%

C20H31NO3 (488737-41-3) → n-dodecylmaleimide (17616-03-4)

Guidance literature:

In toluene; Heating;

DOI:10.1021/ja070828m

Reference yield: 59.3%

maleic dodecylamide (100581-97-3) → n-dodecylmaleimide (17616-03-4)

Guidance literature:

With sodium acetate; triethylamine; at 101 ℃;

DOI:10.3390/molecules23112878

upstream raw materials:

maleic anhydride

n-Dodecylamine

(Z)-4-(dodecylamino)-4-oxobut-2-enoic acid

C₂₀H₃₁NO₃

Downstream raw materials:

2,3-bis(biphenyl-4-yl)-N-dodecylmaleimide

2,3-diphenyl-N-dodecylmaleimide

2-(biphenyl-4-yl)-N-dodecylmaleimide

N,N'-bis-n-dodecyl-1,6-bis(3,5-bis(1-octyloxy)phenyl)tetracene-2,3,8,9-bisimide

Refernces

• 1、 Grosa,Viola,Ceruti,Brusa,Delprino,Dosio,Cattel. "Synthesis and biological activity of a squalenoid maleimide and other classes of squalene derivatives as irreversible inhibitors of 2,3-oxidosqualene cyclase". . p. 17 - 23. Retrieved 1994.
• 2、 -. "MANUFACTURING METHOD OF N-SUBSTITUTED MALEIMIDE". Paragraph 0061-0064; 0065-0066; 0067-0068. . Retrieved 2018/04/06.
• 3、 Zhou, Jie,Cai, Xingguang,Huang, Xun,Dai, Yuxuan,Sun, Lidan,Zhang, Bo,Yang, Bo,Lin, Haiyan,Huang, Wenlong,Qian, Hai. "A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects". . p. 1158 - 1169. Retrieved 2017/08/02.