4-Fluorophenyl 4-methoxyphenyl sulfone

Base Information

• Chemical Name: 4-Fluorophenyl 4-methoxyphenyl sulfone
• CAS No.: 339-25-3
• Molecular Formula: C13H11FO3S
• Molecular Weight: 266.293
• European Community (EC) Number: 654-216-0
• NSC Number: 108693
• DSSTox Substance ID: DTXSID10296295
• Nikkaji Number: J1.998.390K
• Wikidata: Q82036819
• Mol file: 339-25-3.mol

Synonyms:4-fluorophenyl 4-methoxyphenyl sulfone;339-25-3;1-(4-fluorophenyl)sulfonyl-4-methoxybenzene;NSC108693;SCHEMBL7940609;DTXSID10296295;AKOS024332928;NSC-108693

Chemical Property of 4-Fluorophenyl 4-methoxyphenyl sulfone

Chemical Property:

• Vapor Pressure: 1.77E-06mmHg at 25°C
• Boiling Point: 407.5°Cat760mmHg
• Flash Point: 200.2°C
• PSA: 51.75000
• Density: 1.292g/cm³
• LogP: 3.74790
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 266.04129354
• Heavy Atom Count: 18
• Complexity: 347

Purity/Quality:

99%min ^*data from raw suppliers

4-FLUOROPHENYL 4-METHOXYPHENYL SULFONE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)F

Technology Process of 4-Fluorophenyl 4-methoxyphenyl sulfone

There total 14 articles about 4-Fluorophenyl 4-methoxyphenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-methoxybenzenediazonium tetrafluoroborate (459-64-3) + sodium 4-fluorobenzenesulfinate (824-80-6) → 1-fluoro-4-((4-methoxyphenyl)sulfonyl)benzene (339-25-3)

Guidance literature:

With eosin; In water; acetonitrile; at 20 ℃; for 15h; Irradiation; Inert atmosphere;

DOI:10.1039/c9ob00864k

Reference yield: 82.0%

bis(4-fluorophenyl)iodonium triflate (732306-64-8) + 4-methoxyphenylboronic acid (5720-07-0) → 1-fluoro-4-((4-methoxyphenyl)sulfonyl)benzene (339-25-3)

Guidance literature:

With potassium disulphite; 1,3-bis(2,6-di-i-propylphenyl)ylidene gold chloride; sodium carbonate; In acetonitrile; at 100 ℃; for 24h; chemoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.8b03957

Reference yield: 75.0%

4-fluoro-4'-hydroxydiphenyl sulfone (312-36-7) + methyl iodide (74-88-4) → 1-fluoro-4-((4-methoxyphenyl)sulfonyl)benzene (339-25-3)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.583333h; Sonication;

DOI:10.1002/asia.201900423

upstream raw materials:

bis(p-fluorophenyl)sulfone

potassium ethoxide

4-Fluorobenzenesulfonyl chloride

methoxybenzene

Downstream raw materials:

4-fluoro-4'-hydroxydiphenyl sulfone

Refernces

• 1、 Zhu, Haibo,Yang, Liu,Meng, Jia,Xie, Zongbo,Le, Zhang-Gao,Tu, Tao. "Pd/NHC-catalyzed arylsulfonylation of boronic acids: A general and direct protocol to access diarylsulfones". supporting information. . Retrieved 2020/12/29.
• 2、 Zhu, Haibo,Shen, Yajing,Wen, Daheng,Le, Zhang-Gao,Tu, Tao. "Selective Synthesis of ortho-Substituted Diarylsulfones by Using NHC-Au Catalysts under Mild Conditions". supporting information. p. 974 - 979. Retrieved 2019/02/14.