4-FLUOROBENZENESULFINIC ACID SODIUM SALT

Base Information

• Chemical Name: 4-FLUOROBENZENESULFINIC ACID SODIUM SALT
• CAS No.: 824-80-6
• Molecular Formula: C6H4FNaO2S
• Molecular Weight: 182.151
• Hs Code.: 2930909090
• Mol file: 824-80-6.mol

Synonyms:Benzenesulfinicacid, 4-fluoro-, sodium salt (9CI);Benzenesulfinic acid, p-fluoro-, sodiumsalt (6CI,7CI,8CI);NSC 131873;Sodium p-fluorobenzenesulfinate;

Chemical Property of 4-FLUOROBENZENESULFINIC ACID SODIUM SALT

Chemical Property:

• Vapor Pressure: 7.09E-05mmHg at 25°C
• Melting Point: >250 °C
• Boiling Point: 329.5 °C at 760 mmHg
• Flash Point: 153.1°C
• PSA: 77.80000
• LogP: 1.80080
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

4-Flurobenzenesulfinicacidsodiumsalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUOROBENZENESULFINIC ACID SODIUM SALT

There total 9 articles about 4-FLUOROBENZENESULFINIC ACID SODIUM SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) → sodium 4-fluorobenzenesulfinate (824-80-6)

Guidance literature:

With sodium hydrogencarbonate; sodium sulfite; In water; at 80 ℃; for 4h;

Reference yield: 86.0%

→ sodium 4-fluorobenzenesulfinate (824-80-6)

Guidance literature:

Reference yield: 74.0%

1-Bromo-4-fluorobenzene (460-00-4) → sodium 4-fluorobenzenesulfinate (824-80-6)

Guidance literature:

1-Bromo-4-fluorobenzene; With iodine; magnesium; In tetrahydrofuran; at 100 ℃; for 1h; Inert atmosphere; Microwave irradiation;

With 1,4-diazabicyclo [2.2.2] octane-1,4-diium-1,4-disulfinate; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

With sodium carbonate; In tetrahydrofuran; diethyl ether; water;

DOI:10.1016/j.tetlet.2015.12.073

upstream raw materials:

β-(Diisopropylamino)ethyl p-fluorobenzenethiosulfonate

4-Fluorobenzenesulfonyl chloride

Potassium p-Fluorobenzenethiosulfonic Acid

1-Bromo-4-fluorobenzene

Downstream raw materials:

4-(phenylsulfonyl)fluorobenzene

8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-fluorophenyl)sulfonyl]quinoline

bis(4-fluorophenyl)disulfide

[3-butoxy-5-(4-fluoro-benzenesulfonyl)-phenyl]-acetic acid methyl ester

Refernces

• 1、 Chen, Yi-Xuan,Wang, Zhu-Jun,Xiao, Jun-An,Chen, Kai,Xiang, Hao-Yue,Yang, Hua. "Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol". supporting information. p. 6558 - 6562. Retrieved 2021/08/23.
• 2、 Qiu, Di,Li, Songyi,Yue, Guanglu,Mao, Jinshan,Xu, Bei,Yuan, Xinyu,Ye, Fei. "Synthesis of arylboronates via the Pd-catalyzed desulfitative coupling reaction of sodium arylsulfinates with bis(pinacolato)diboron". supporting information. . Retrieved 2021/11/04.