Technology Process of 8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-fluorophenyl)sulfonyl]quinoline
There total 6 articles about 8-[(3,3-difluoro-1-piperidinyl)methyl]-3-[(4-fluorophenyl)sulfonyl]quinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(II) bis(trifluoromethanesulfonate); potassium carbonate; N,N-dimethylethylenediamine;
In
dimethyl sulfoxide;
at 100 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Heating / reflux
2.1: N-iodo-succinimide / Heating / reflux
2.2: 0.5 h
3.1: potassium hydroxide; water / methanol / 2 h / Heating / reflux
4.1: manganese(IV) oxide / dichloromethane / 4.5 h / 20 °C
5.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C
6.1: copper(I) triflate; potassium carbonate; N,N-dimethylethylenediamine / dimethyl sulfoxide / 100 °C
With
manganese(IV) oxide; potassium hydroxide; N-Bromosuccinimide; N-iodo-succinimide; water; copper(I) triflate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N,N-dimethylethylenediamine; dibenzoyl peroxide;
In
methanol; tetrachloromethane; dichloromethane; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-iodo-succinimide / Heating / reflux
1.2: 0.5 h
2.1: potassium hydroxide; water / methanol / 2 h / Heating / reflux
3.1: manganese(IV) oxide / dichloromethane / 4.5 h / 20 °C
4.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C
5.1: copper(I) triflate; potassium carbonate; N,N-dimethylethylenediamine / dimethyl sulfoxide / 100 °C
With
manganese(IV) oxide; potassium hydroxide; N-iodo-succinimide; water; copper(I) triflate; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; N,N-dimethylethylenediamine;
In
methanol; dichloromethane; dimethyl sulfoxide;