ISOQUINOLIN-6-YLMETHANOL

Base Information

• Chemical Name: ISOQUINOLIN-6-YLMETHANOL
• CAS No.: 188861-59-8
• Molecular Formula: C10H9NO
• Molecular Weight: 159.18500
• Hs Code.: 2933499090
• Mol file: 188861-59-8.mol

Synonyms:6-isoquinoline-methanol;

Chemical Property of ISOQUINOLIN-6-YLMETHANOL

Chemical Property:

• Vapor Pressure: 1.44E-05mmHg at 25°C
• Boiling Point: 352.3oC at 760 mmHg
• PKA: 14.06±0.10(Predicted)
• Flash Point: 166.9oC
• PSA: 33.12000
• Density: 1.218g/cm3
• LogP: 1.72710

Purity/Quality:

98%min ^*data from raw suppliers

Isoquinolin-6-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Isoquinolin-6-ylmethanol is a starting material and useful building block of various pharmaceuticals.

Technology Process of ISOQUINOLIN-6-YLMETHANOL

There total 2 articles about ISOQUINOLIN-6-YLMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

isoquinoline-6-carboxylic acid methyl ester (173089-82-2) → (isoquinolin-6-yl)methanol (188861-59-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 25 ℃; for 1h;

Reference yield:

isoquinoline-6-carboxylic acid (106778-43-2) → (isoquinolin-6-yl)methanol (188861-59-8)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 12 h / 65 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 25 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran;

Reference yield:

(isoquinolin-6-yl)methanol (188861-59-8) → 6-isoquinoline carboxaldehyde (173089-81-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 1h;

upstream raw materials:

isoquinoline-6-carboxylic acid methyl ester

isoquinoline-6-carboxylic acid

Downstream raw materials:

6-isoquinoline carboxaldehyde

Refernces

• 1、 -. "SUBSTITUTED 6,7-DIALKOXY-3-ISOQUINOLINOL DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE10A)". Page/Page column 36. . Retrieved 2012/09/05.