6-isoquinolinecarboxylic acid

Base Information

• Chemical Name: 6-isoquinolinecarboxylic acid
• CAS No.: 106778-43-2
• Molecular Formula: C10H7 N O2
• Molecular Weight: 173.171
• Hs Code.: 2933499090
• Mol file: 106778-43-2.mol

Synonyms:6-isoquinolinecarboxylic acid;isoquinoline-6-carboxylic acid

Chemical Property of 6-isoquinolinecarboxylic acid

Chemical Property:

• Vapor Pressure: 5.15E-06mmHg at 25°C
• Melting Point: 355-360 °C
• Boiling Point: 366.4oC at 760 mmHg
• PKA: 3.03±0.30(Predicted)
• Flash Point: 175.4oC
• PSA: 50.19000
• Density: 1.339g/cm3
• LogP: 1.93300
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Isoquinoline-6-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-isoquinolinecarboxylic acid

There total 4 articles about 6-isoquinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

→ isoquinoline-6-carboxylic acid (106778-43-2)

Guidance literature:

Reference yield: 81.0%

isoquinoline-6-carboxylic acid methyl ester (173089-82-2) → isoquinoline-6-carboxylic acid (106778-43-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran;

DOI:10.1016/S0960-894X(99)00435-7

Reference yield: 21.0%

isoquinoline-6-carbonitrile (106778-42-1) → isoquinoline-6-carboxylic acid (106778-43-2)

Guidance literature:

isoquinoline-6-carbonitrile; With potassium hydroxide; In diethylene glycol; at 160 ℃; for 3h;

With hydrogenchloride; In water; diethylene glycol;

upstream raw materials:

isoquinoline-6-carbonitrile

isoquinoline-6-carboxylic acid methyl ester

6-bromo-isoquinoline

Downstream raw materials:

methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate

6-isoquinoline carboxaldehyde

(isoquinolin-6-yl)methanol

C₁₀H₆ClNO

Refernces

• 1、 -. "Preparation method of 1-aminoisoquinoline-6-methanol". Paragraph 0020; 0024. . Retrieved 2017/08/29.
• 2、 -. "Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith". Page/Page column 33. . Retrieved 2008/12/07.