Methylphosphinic acid

Base Information

• Chemical Name: Methylphosphinic acid
• CAS No.: 4206-94-4
• Molecular Formula: CH5 O2 P
• Molecular Weight: 80.0233
• Hs Code.: 2931900090
• European Community (EC) Number: 224-125-7
• DSSTox Substance ID: DTXSID30871063
• Wikipedia: Methylphosphinic_acid
• Wikidata: Q27093805
• Mol file: 4206-94-4.mol

Synonyms:methylphosphinic acid

Chemical Property of Methylphosphinic acid

Chemical Property:

• Vapor Pressure: 0.862mmHg at 25°C
• Boiling Point: 192.5°Cat760mmHg
• PKA: pK1:3.08 (25°C)
• Flash Point: 70.2°C
• PSA: 60.77000
• Density: g/cm³
• LogP: 0.08320
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 78.99489136
• Heavy Atom Count: 4
• Complexity: 33

Purity/Quality:

99% ^*data from raw suppliers

METHYL-PHOSPHINIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[P+](=O)O

Technology Process of Methylphosphinic acid

There total 21 articles about Methylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl phosphine hydrochloride → methylphosphinic acid (4206-94-4)

Guidance literature:

With dimethyl sulfoxide; In water; at 50 ℃; for 2h; Cooling; Green chemistry;

Reference yield: 100.0%

O-ethyl(methyl)diethoxymethyl phosphinate (112499-26-0) → methylphosphinic acid (4206-94-4)

Guidance literature:

With hydrogenchloride; water; for 24h; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.200900852

Reference yield: 82.0%

bis(trimethylsilyl)phosphonite (30148-50-6) + methyl iodide (74-88-4) → dimethylphosphinic acid (3283-12-3) + methylphosphinic acid (4206-94-4)

Guidance literature:

bis(trimethylsilyl)phosphonite; methyl iodide; In dichloromethane; at 0 - 20 ℃; for 14h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 0 - 20 ℃; for 2h;

DOI:10.1039/c2ob26395e

upstream raw materials:

ethanol

methylphosphonothioic acid

2-(N-phenylacetamido)ethyl hydrogen methylphosphonite

methyl iodide

Downstream raw materials:

methylphosphine

methylphosphonic acid

methylidynephosphine

methyl-o-benzylphosphinic acid

Refernces

• 1、 -. "One-pot preparation method of methyl aluminum hypophosphite". Paragraph 0041-0043; 0054-0057. . Retrieved 2019/02/13.
• 2、 -. "PROCESS FOR PREPARING METHYL PHOSPHINIC ACID BUTYL ESTER". Page/Page column 36; 37. . Retrieved 2018/09/19.