N,N-dimethyl-4-(trifluoromethyl)benzamide

Base Information

• Chemical Name: N,N-dimethyl-4-(trifluoromethyl)benzamide
• CAS No.: 25771-21-5
• Molecular Formula: C10H10 F3 N O
• Molecular Weight: 217.191
• Hs Code.: 2924299090
• Mol file: 25771-21-5.mol

Synonyms:p-Toluamide,a,a,a-trifluoro-N,N-dimethyl- (8CI); N,N-Dimethyl-4-(trifluoromethyl)benzamide

Chemical Property of N,N-dimethyl-4-(trifluoromethyl)benzamide

Chemical Property:

• Vapor Pressure: 0.00486mmHg at 25°C
• Melting Point: 65-75 °C
• Boiling Point: 276.2°Cat760mmHg
• PKA: -1.77±0.70(Predicted)
• Flash Point: 120.9°C
• PSA: 20.31000
• Density: 1.218g/cm³
• LogP: 2.40720
• Storage Temp.: Room temperature.

Purity/Quality:

≥95% ^*data from raw suppliers

N,N-dimethyl-4-(trifluoromethyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-dimethyl-4-(trifluoromethyl)benzamide

There total 22 articles about N,N-dimethyl-4-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-trifluoromethyl-phenyl acetyl chloride (329-15-7) + dimethyl amine (124-40-3) → N,N-dimethyl 4-(trifluoromethyl)benzamide (25771-21-5)

Guidance literature:

In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.75h; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.07.040

Reference yield: 96.0%

4-trifluoromethylbenzoic acid (455-24-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethyl 4-(trifluoromethyl)benzamide (25771-21-5)

Guidance literature:

With sulfur trioxide pyridine complex; at 160 ℃; Reagent/catalyst; Temperature; Schlenk technique; Inert atmosphere;

DOI:10.1246/cl.171216

Reference yield: 92.0%

4-Iodobenzotrifluoride (455-13-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethyl 4-(trifluoromethyl)benzamide (25771-21-5)

Guidance literature:

With trichlorophosphate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; at 120 ℃; for 24h;

DOI:10.1021/ol026236k

upstream raw materials:

4-Iodobenzotrifluoride

N,N-dimethyl-formamide

4-trifluoromethyl-phenyl acetyl chloride

dimethylamine dihydrochloride

Downstream raw materials:

2-(trifluoromethyl)-1-[4-(trifluoromethyl)phenyl]prop-2-en-1-one

1-(4-trifluoromethylphenyl)-5-hexen-1-one

C₁₃H₁₅F₃O

C₁₃H₁₄F₃IO

Refernces

• 1、 Tan, Xuefeng,Massignan, Leonardo,Hou, Xiaoyan,Frey, Johanna,Oliveira, Jo?o C. A.,Hussain, Masoom Nasiha,Ackermann, Lutz. "Rhoda-Electrocatalyzed Bimetallic C?H Oxygenation by Weak O-Coordination". supporting information. p. 13264 - 13270. Retrieved 2021/05/06.
• 2、 Baumann, Marcus,Bonciolini, Stefano,Di Filippo, Mara. "A scalable continuous photochemical process for the generation of aminopropylsulfones". supporting information. p. 9428 - 9432. Retrieved 2020/12/15.