455-24-3Relevant articles and documents
Acid/base-catalyzed ester hydrolysis in near-critical water
Lesutis, Heather P.,Glaeser, Roger,Liotta, Charles L.,Eckert, Charles A.
, p. 2063 - 2064 (1999)
Hydrolyses of substituted benzoic acid esters in near-critical water (250-300°C) show autocatalytic kinetic behavior and surprisingly give the same rate constant regardless of substituent, suggesting that an acid-catalyzed mechanism predominates under our reaction conditions.
Mechanochemical Grignard Reactions with Gaseous CO2 and Sodium Methyl Carbonate**
Pfennig, Victoria S.,Villella, Romina C.,Nikodemus, Julia,Bolm, Carsten
supporting information, (2022/01/22)
A one-pot, three-step protocol for the preparation of Grignard reagents from organobromides in a ball mill and their subsequent reactions with gaseous carbon dioxide (CO2) or sodium methyl carbonate providing aryl and alkyl carboxylic acids in up to 82 % yield is reported. Noteworthy are the short reaction times and the significantly reduced solvent amounts [2.0 equiv. for liquid assisted grinding (LAG) conditions]. Unexpectedly, aryl bromides with methoxy substituents lead to symmetric ketones as major products.
Milled Dry Ice as a C1 Source for the Carboxylation of Aryl Halides
O'Brien, Connor J.,Nicewicz, David A.
supporting information, p. 814 - 816 (2021/03/01)
The use of carbon dioxide as a C1 chemical feedstock remains an active field of research. Here we showcase the use of milled dry ice as a method to promote the availability of CO 2in a reaction solution, permitting practical synthesis of arylcarboxylic acids. Notably, the use of milled dry ice produces marked increases in yields relative to those obtained with gaseous CO 2, as previously reported in the literature.