347-80-8

Basic information

• Product Name: Benzamide, N-phenyl-4-(trifluoromethyl)-
• CAS NO: 347-80-8
• Molecular Formula: C14H10F3NO
• Molecular Weight: 265.235
• Mol File: 347-80-8.mol
• Article Data: 43

Chemical Properties

• CAS DataBase Reference: Benzamide, N-phenyl-4-(trifluoromethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-phenyl-4-(trifluoromethyl)-(347-80-8)
• EPA Substance Registry System: Benzamide, N-phenyl-4-(trifluoromethyl)-(347-80-8)

Safety Data

• Hazardous Substances Data: 347-80-8(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 98-56-6 4-chlorobenzotrifluoride 
• 62-53-3 aniline 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 66003-76-7 Diphenyliodonium triflate 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 98-95-3 nitrobenzene 
• 57710-82-4 (1H-benzo[d][1,2,3]triazol-1-yl)(4-(trifluoromethyl)phenyl)methanone 
• 95-14-7 1,2,3-Benzotriazole 
• 3422-02-4 N-(benzyloxycarbonyl)aniline 
• 3422-01-3 tert-butyl phenylcarbamate 
• 18992-89-7 allyl N-phenylcarbamate 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 21084-31-1 (4-(dimethylamino)phenyl)(4-(trifluoromethyl)phenyl)methanone 
• 6833-18-7 4-methyl-N-phenylbenzamide 
• 134384-31-9 2-(4-trifluoromethylphenyl)benzothiazole 
• 1229610-06-3 4-phenyl-2-(4-(trifluoromethyl)phenyl)quinazoline 
• 1281681-07-9 3-(N-phenyl-4-trifluoromethylphenylacetimidoyl)-1-(3-pyridylmethyl)thiourea 
• 425366-01-4 N-phenyl-4-trifluoromethyl-benzimidic acid 4-cyano-phenyl ester 
• 425366-17-2 phenyl-(4-trifluoromethyl-phenylmethylidyne)-ammonium 
• 339094-67-6 N-cyclohexyl-4-(trifluoromethyl)benzamide 
• 785708-07-8 N-(4-bromophenyl)-4-(trifluoromethyl)benzamide 

Relevant articles and documents

An oxidative rearrangement of C,N-diarylaldimines to formamides using sodium perborate

Treatment of C,N-diaryladium (5) with sodium tetrahydrate in triflouroacetic acid solution at 70-80° C results in an oxidative rearrangement to N,N-diarylformamides (6(Scheme 1). A mechanism involving the initial formation of 2,3-diaryloxaziridines is proposed (Scheme 2).

Cobalt-Catalyzed Deoxygenative Hydroboration of Nitro Compounds and Applications to One-Pot Synthesis of Aldimines and Amides

The commercially available and bench-stable Co(acac)2 ligated with bis[(2-diphenylphosphino)phenyl] ether (dpephos) was employed for selective room temperature hydroboration of nitro compounds with HBPin (TOF up to 4615 h?1), tolerating halide, hydroxy, amino, ether, ester, lactone, amide and heteroaromatic functionalities. These reactions offered a direct access to a variety of N-borylamines RN(H)BPin, which were in situ treated with aldehydes and carboxylic acids to produce a series of aldimines and secondary carboxamides without the need for dehydrating and/or coupling reagents. Combination of these transformations in a sequential one-pot manner allowed for direct and selective synthesis of aldimines and secondary carboxamides from readily available and inexpensive nitro compounds.

Selective hydrogenation dehalogenation method of ortho-halogenated acylaniline

The invention discloses a selective hydrogenation dehalogenation method of copper-catalyzed ortho-halogenated acylaniline. The method comprises the following steps: by using ortho-halogenated acylaniline as a starting raw material and copper acetylacetonate/vasicine as a catalyst, adding an organic alkali, reacting in an alcoholic solution at 80-100 DEG C for 12 hours, and regioselectively catalytically hydrogenating ortho-bromine and iodine atoms. The preparation method has the characteristics of simplicity and convenience in operation, wide substrate application range, low cost, high regioselectivity and the like, and has practicability.