3,6-Dihydro-4-methyl-2H-pyran

Base Information

• Chemical Name: 3,6-Dihydro-4-methyl-2H-pyran
• CAS No.: 16302-35-5
• Molecular Formula: C6H10 O
• Molecular Weight: 98.1448
• Hs Code.: 2932999099
• European Community (EC) Number: 240-390-1
• UNII: 6G5QBA6SSS
• DSSTox Substance ID: DTXSID00167501
• Nikkaji Number: J157.832D
• Wikidata: Q63398708
• Mol file: 16302-35-5.mol

Synonyms:3,6-Dihydro-4-methyl-2H-pyran;16302-35-5;4-methyl-3,6-dihydro-2H-pyran;2H-Pyran, 3,6-dihydro-4-methyl-;EINECS 240-390-1;4-methyl-5,6-dihydro-2h-pyran;6G5QBA6SSS;UNII-6G5QBA6SSS;AMY5953;DTXSID00167501;DIHYDRO-4-METHYL-2H-PYRAN;4-methyl-5,6-dihydro-(2H)-pyran;MFCD00040465;AKOS025296253;CS-W004276;LS-185641;FT-0764161;F17726;Q63398708

Chemical Property of 3,6-Dihydro-4-methyl-2H-pyran

Chemical Property:

• Vapor Pressure: 17.8mmHg at 25°C
• Refractive Index: 1.4495
• Boiling Point: 121.1°Cat760mmHg
• Flash Point: 14.3°C
• PSA: 9.23000
• Density: 0.902g/cm³
• LogP: 1.35300
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 98.073164938
• Heavy Atom Count: 7
• Complexity: 84.2

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CCOCC1
• Use Description: 3,6-dihydro-4-methyl-2H-pyran, a chemical compound with a versatile structure, has several applications across different fields. In the fragrance and flavor industry, it serves as a valuable ingredient for creating pleasant and aromatic scents, as well as enhancing the taste profiles of various food and beverage products. Its role is pivotal in giving a fruity and caramel-like aroma and flavor to a range of consumables. Additionally, in organic chemistry and chemical synthesis, this compound can act as a building block for the creation of more complex molecules, making it valuable for research and drug development. Its multifaceted utility underscores its significance in enhancing sensory experiences in the food and fragrance industries, as well as its role in advancing chemical research and innovation.

Technology Process of 3,6-Dihydro-4-methyl-2H-pyran

There total 24 articles about 3,6-Dihydro-4-methyl-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-methylene-tetrahydro-pyran (36838-71-8) → 4-methyl-3,6-dihydro-2H-pyran (16302-35-5) + 4-methyl-3,4-dihydro-2H-pyran (2270-61-3)

Guidance literature:

With sodium hydroxide; iron pentacarbonyl; at 180 ℃; for 10h; Product distribution; autoclave, other time;

DOI:10.1007/BF00506660

Reference yield: 65.0%

[(Z)-4-(2-Methoxy-ethoxymethoxy)-2-methyl-but-1-enyl]-trimethyl-silane → 4-methyl-3,6-dihydro-2H-pyran (16302-35-5)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at -20 ℃; for 1h;

DOI:10.1021/ja00266a034

Reference yield: 63.0%

3,4-dibromo-4-methyltetrahydropyran (79862-81-0) + diethyl malonate (105-53-3) → 4-methyl-3,6-dihydro-2H-pyran (16302-35-5) + tetraethyl ethane-1,1,2,2-tetracarboxylate (632-56-4)

Guidance literature:

In ethanol;

DOI:10.1023/B:RUJO.0000010200.00341.d0

upstream raw materials:

4,4-dimethyl-1,3-dioxane

ethyl acetate

4-methylene-tetrahydro-pyran

4-hydroxy-4-methyltetrahydropyran

Downstream raw materials:

trans-3-hydroxymethyl-4-hydroxy-4-methyltetrahydropyran

trans-10-methyl-1,3,7-trioxadecalin

cis-10-methyl-1,3,7-trioxadecalin

3-hydroxymethyl-4-methyl-3,6-dihydropyran

Refernces

• 1、 Overman, Larry E.,Castaneda, Armando,Blumenkopf, Todd A.. "Acetal-Initiated Cyclization of Vinylsilanes. A General Synthesis of Allylically Unsaturated Oxacyclics". . p. 1303 - 1304. Retrieved 1986.
• 2、 Sushkevich,Ordomsky,Ivanova. "Synthesis of isoprene from formaldehyde and isobutene over phosphate catalysts". . p. 21 - 29. Retrieved 2012/11/07.