3,4-Dihydro-4-methyl-2H-pyran

Base Information

• Chemical Name: 3,4-Dihydro-4-methyl-2H-pyran
• CAS No.: 2270-61-3
• Molecular Formula: C6H10 O
• Molecular Weight: 98.1448
• Hs Code.: 2932999099
• European Community (EC) Number: 218-875-4
• DSSTox Substance ID: DTXSID60945367
• Nikkaji Number: J100.700I
• Mol file: 2270-61-3.mol

Synonyms:3,4-Dihydro-4-methyl-2H-pyran;2270-61-3;4-Methyl-3,4-dihydro-2H-pyran;2H-Pyran, 3,4-dihydro-4-methyl-;EINECS 218-875-4;4-Methyl-2,3-dihydropyran;4-methyldihydro-2h-pyran;DTXSID60945367;4-Methyl-3,4-dihydro-2H-pyran #

Chemical Property of 3,4-Dihydro-4-methyl-2H-pyran

Chemical Property:

• Vapor Pressure: 20.7mmHg at 25°C
• Boiling Point: 117.5°Cat760mmHg
• Flash Point: 17.3°C
• PSA: 9.23000
• Density: 0.885g/cm³
• LogP: 1.55650
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 98.073164938
• Heavy Atom Count: 7
• Complexity: 76.2

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CCOC=C1

Technology Process of 3,4-Dihydro-4-methyl-2H-pyran

There total 15 articles about 3,4-Dihydro-4-methyl-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-methoxy-3,6-dihydro-2H-pyran (6559-34-8) + methylmagnesium bromide (75-16-1) → 4-methyl-3,4-dihydro-2H-pyran (2270-61-3) + 6-methyl-3,6-dihydro-2H-pyran (55230-25-6)

Guidance literature:

With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In tetrahydrofuran; at 80 ℃; for 4h;

DOI:10.1016/S0040-4039(98)00162-2

Reference yield: 90.0%

4-Methyl-3,4,5,6-tetrahydro-2H-pyran-2-ol (18653-57-1) → 4-methyl-3,4-dihydro-2H-pyran (2270-61-3)

Guidance literature:

With phosphoric acid; at 180 ℃; Reagent/catalyst; Inert atmosphere;

Reference yield: 75.0%

4-methylene-tetrahydro-pyran (36838-71-8) → 4-methyl-3,6-dihydro-2H-pyran (16302-35-5) + 4-methyl-3,4-dihydro-2H-pyran (2270-61-3)

Guidance literature:

With sodium hydroxide; iron pentacarbonyl; at 180 ℃; for 10h; Product distribution; autoclave, other time;

DOI:10.1007/BF00506660

upstream raw materials:

2-Butoxy-3,4,5,6-tetrahydro-4-methyl-2H-pyran

4-methyl-2-ethoxytetrahydropyran

4-methyl-3,6-dihydro-2H-pyran

4-methylene-tetrahydro-pyran

Downstream raw materials:

Acetic acid (2E,6E)-9-benzenesulfonyl-3,7-dimethyl-8-(4-methyl-tetrahydro-pyran-2-yloxy)-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,6-dienyl ester

2-(2,4-Dichlorphenoxy)-3,4,5,6-tetrahydro-4-methyl-2H-pyran

trans-2-hydroxy-4-methyltetrahydropyran

cis-2-hydroxy-4-methyltetrahydropyran

Refernces

• 1、 -. "METHOD OF PRODUCING 4-METHYL-3,4-DIHYDRO-2H-PYRAN". Paragraph 0025. . Retrieved 2017/01/31.
• 2、 Wildman, Tanya,Kocienski, Philip J.,Narquizian, Robert,Whittingham, William G.. "A synthesis of 6-tributylstannyl-3,4-dihydro-2H-pyrans via coupling of enol triflates with (Bu3Sn)(Bu)Culi·liCN". . p. 393 - 398. Retrieved 2007/10/03.