Pentanenitrile, 3-(acetyloxy)-, (3R)-

Base Information

• Chemical Name: Pentanenitrile, 3-(acetyloxy)-, (3R)-
• CAS No.: 198561-46-5
• Molecular Formula: C7H11NO2
• Mol file: 198561-46-5.mol

Synonyms:

Chemical Property of Pentanenitrile, 3-(acetyloxy)-, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pentanenitrile, 3-(acetyloxy)-, (3R)-

There total 2 articles about Pentanenitrile, 3-(acetyloxy)-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + 3-hydroxyvaleronitrile (13635-05-7) → (R)-3-hydroxypentanenitrile (198561-27-2) + (S)-3-hydroxypentanenitrile (199177-61-2) + (R)-1-(cyanomethyl)propyl acetate (198561-46-5)

Guidance literature:

With imidazolium alkyl-PEG sulfate ionic liquid coated lipase PS; In di-isopropyl ether; at 35 ℃; optical yield given as %ee; enantioselective reaction; Enzymatic reaction;

DOI:10.1039/c0gc00151a

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + 3-hydroxyvaleronitrile (13635-05-7) → (R)-3-hydroxypentanenitrile (198561-27-2) + (S)-3-hydroxypentanenitrile (199177-61-2) + (R)-1-(cyanomethyl)propyl acetate (198561-46-5) + (S)-1-cyanobutan-2-yl acetate (198561-34-1)

Guidance literature:

With 2,2,3,3,4,4,5,5-octafluoropentyl sulfate; lipase-PS; at 35 ℃; for 11h; Further Variations:; Reagents; Product distribution;

DOI:10.1016/j.tetlet.2006.01.017

Reference yield:

(R)-1-(cyanomethyl)propyl acetate (198561-46-5) → (R)-3-hydroxypentanenitrile (198561-27-2)

Guidance literature:

With Pseudomonas ceracia lipase; water; In acetone; at 35 ℃; Further Variations:; effect of presence of 1,4,8,11-tetrathiacyclotetradecane; Enzyme kinetics; Enzymatic reaction;

DOI:10.1246/bcsj.72.1589

upstream raw materials:

vinyl acetate

3-hydroxyvaleronitrile

Downstream raw materials:

(R)-3-hydroxypentanenitrile

Refernces

• 1、 Abe, Yoshikazu,Yoshiyama, Kazuhide,Yagi, Yusuke,Hayase, Shuichi,Kawatsura, Motoi,Itoh, Toshiyuki. "A rational design of phosphonium salt type ionic liquids for ionic liquid coated-lipase catalyzed reaction". experimental part. p. 1976 - 1980. Retrieved 2011/02/23.