2-Hydroxy-2'-methoxybenzophenone

Base Information

• Chemical Name: 2-Hydroxy-2'-methoxybenzophenone
• CAS No.: 21147-18-2
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• DSSTox Substance ID: DTXSID80434920
• Nikkaji Number: J329.618K
• Wikidata: Q82249519
• Mol file: 21147-18-2.mol

Synonyms:2-hydroxy-2'-methoxybenzophenone;21147-18-2;(2-hydroxyphenyl)(2-methoxyphenyl)methanone;SCHEMBL4060271;DTXSID80434920;HSCIDDFNIHSEDR-UHFFFAOYSA-N

Chemical Property of 2-Hydroxy-2'-methoxybenzophenone

Chemical Property:

• Melting Point: 77°C
• PSA: 46.53000
• LogP: 2.63180
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 264

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(=O)C2=CC=CC=C2O

Technology Process of 2-Hydroxy-2'-methoxybenzophenone

There total 20 articles about 2-Hydroxy-2'-methoxybenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-iodophenyl 2-methoxybenzoate (129103-71-5) → (2-hydroxyphenyl)(2-methoxyphenyl)methanone (21147-18-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; at -70 ℃; for 2h;

DOI:10.1021/jo00302a011

Reference yield: 85.0%

(2-(benzyloxy)-phenyl)(2-methoxyphenyl)methanone (678967-04-9) → (2-hydroxyphenyl)(2-methoxyphenyl)methanone (21147-18-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol;

DOI:10.1021/acs.joc.8b02503

Reference yield: 71.0%

4-iodoanisol (529-28-2) + salicylaldehyde (90-02-8) → (2-hydroxyphenyl)(2-methoxyphenyl)methanone (21147-18-2)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700881

upstream raw materials:

2-iodophenyl 2-methoxybenzoate

2,2'-dihydroxybenzophenone

dimethyl sulfate

(2-(benzyloxy)-phenyl)(2-methoxyphenyl)methanone

Downstream raw materials:

4-(2-Methoxy-phenyl)-2-oxo-2H-chromene-3-carboxylic acid ethyl ester

[2-but-3-enyloxyphenyl](2-methoxyphenyl)methanone

3-(o-methoxyphenyl)-2-phenylbenzo[b]furan

2-benzyloxy-2'-methoxybenzophenone hydrazide

Refernces

• 1、 Clarkson, Guy J.,Wills, Martin,Zheng, Ye. "Asymmetric Transfer Hydrogenation of o-Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols". . . Retrieved 2020/05/05.
• 2、 Ming, Zong-Yao,Li, Kang-Rui,Meng, Fan-Jie,Shi, Lei,Jiang, Wen-Feng. "Efficient visible-light photocatalytic aerobic oxidation of cyclic sulfamides to imines". supporting information. . Retrieved 2020/06/17.