Piperidine, 1,4-diphenyl-

Base Information

• Chemical Name: Piperidine, 1,4-diphenyl-
• CAS No.: 220616-20-6
• Molecular Formula: C17H19N
• Molecular Weight: 237.345
• Mol file: 220616-20-6.mol

Synonyms:

Chemical Property of Piperidine, 1,4-diphenyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Piperidine, 1,4-diphenyl-

There total 20 articles about Piperidine, 1,4-diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-phenylpiperidine (771-99-3) + pivalic acid phenyl ester (4920-92-7) → 1,4-diphenylpiperidine (220616-20-6)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.200907287

Reference yield: 83.0%

4-phenylpiperidine (771-99-3) + Diphenyliodonium triflate (66003-76-7) → 1,4-diphenylpiperidine (220616-20-6)

Guidance literature:

Diphenyliodonium triflate; With sodium carbonate; Inert atmosphere; Sealed tube;

4-phenylpiperidine; In toluene; at 110 ℃; regiospecific reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201807001

Reference yield: 81.0%

4-phenylpiperidine (771-99-3) + chlorobenzene (108-90-7) → 1,4-diphenylpiperidine (220616-20-6)

Guidance literature:

With dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II); potassium tert-butylate; In neat (no solvent); for 3h; Milling;

DOI:10.1039/c8ob01781f

upstream raw materials:

1,4-dioxane

3-phenyl-glutaric acid bis-pentylamide

4-phenylpiperidine

phenyl trimethylsiloxane

Refernces

• 1、 Chan, Dominic M. T.,Monaco, Kevin L.,Li, Renhua,Bonne, Damien,Clark, Charles G.,Lam, Patrick Y. S.. "Copper promoted C-N and C-O bond cross-coupling with phenyl and pyridylboronates". . p. 3863 - 3865. Retrieved 2003.
• 2、 Nishizawa, Akihiro,Takahira, Tsuyoshi,Yasui, Kosuke,Fujimoto, Hayato,Iwai, Tomohiro,Sawamura, Masaya,Chatani, Naoto,Tobisu, Mamoru. "Nickel-Catalyzed Decarboxylation of Aryl Carbamates for Converting Phenols into Aromatic Amines". supporting information. p. 7261 - 7265. Retrieved 2019/05/16.
• 3、 Shimasaki, Toshiaki,Tobisu, Mamoru,Chatani, Naoto. "Nickel-catalyzed amination of aryl Pivalates by the cleavage of aryl C-O bonds". supporting information; experimental part. p. 2929 - 2932. Retrieved 2010/06/15.