4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-phenyl-

Base Information

• Chemical Name: 4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-phenyl-
• CAS No.: 23050-38-6
• Molecular Formula: C18H16O5
• Molecular Weight: 312.322
• Mol file: 23050-38-6.mol

Synonyms:4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-phenyl-;5,7,8-Trimethoxy-2-phenyl-4H-1-benzopyran-4-one;Flavone, 5,7,8-trimethoxy- (7CI,8CI);

Chemical Property of 4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-phenyl-

Chemical Property:

• PSA: 57.90000
• LogP: 3.48580

Purity/Quality:

99%+, ^*data from raw suppliers

5,7,8-Trimethoxyflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-phenyl-

There total 24 articles about 4H-1-Benzopyran-4-one, 5,7,8-trimethoxy-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5,7-dimethoxy-8-bromo-flavone (42079-76-5) + sodium methylate (124-41-4) → 5,7,8-trimethoxy-2-phenyl-chromen-4-one (23050-38-6)

Guidance literature:

sodium methylate; With copper(ll) bromide; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 1h;

5,7-dimethoxy-8-bromo-flavone; In methanol; N,N-dimethyl-formamide; at 120 ℃; for 0.666667h; Temperature; Reagent/catalyst;

Reference yield:

Dimethyl-chrysin (21392-57-4) + methyl iodide (74-88-4) → 5,6,7-trimethoxyflavone (973-67-1) + 5,7,8-trimethoxy-2-phenyl-chromen-4-one (23050-38-6)

Guidance literature:

Dimethyl-chrysin; With dihydrogen peroxide; methyltrioxorhenium(VII); In methanol; water; at 25 ℃; for 2h;

methyl iodide; In N,N-dimethyl-formamide; at 25 ℃; for 24h; Further stages.;

DOI:10.1016/j.tet.2008.05.101

Reference yield:

2'-hydroxy-3',4',6'-trimethoxychalcone (91856-16-5,6971-20-6) → 5,7,8-trimethoxy-2-phenyl-chromen-4-one (23050-38-6)

Guidance literature:

With selenium(IV) oxide; In pentan-1-ol; for 24h; Heating;

upstream raw materials:

diazomethane

wogonin

1-(2-hydroxy-3,4,6-trimethoxy-phenyl)-3-phenyl-propane-1,3-dione

norwogonin

Downstream raw materials:

5,8-dihydroxy-7-methoxyflavone

(E)-3-(2-hydroxy-3,4,6-trimethoxyphenyl)-1-phenylprop-2-en-1-one

5,7,8-triacetoxy-2-phenyl-chromen-4-one

5-Acetoxy-7,8-dimethoxy-flavon

Refernces

• 1、 Bernini, Roberta,Mincione, Enrico,Provenzano, Gianfranco,Fabrizi, Giancarlo,Tempesta, Sabrina,Pasqualetti, Marcella. "Obtaining new flavanones exhibiting antifungal activities by methyltrioxorhenium-catalyzed epoxidation-methanolysis of flavones". . p. 7561 - 7566. Retrieved 2008/12/20.