Wogonin

Base Information

• Chemical Name: Wogonin
• CAS No.: 632-85-9
• Molecular Formula: C16H12O5
• Molecular Weight: 284.268
• Hs Code.: 29329990
• Mol file: 632-85-9.mol

Synonyms:Flavone,5,7-dihydroxy-8-methoxy- (7CI,8CI);Wogonin (6CI);5,7-Dihydroxy-8-methoxyflavone;

Chemical Property of Wogonin

Chemical Property:

• Appearance/Colour: yellow crystal
• Vapor Pressure: 2.21E-11mmHg at 25°C
• Melting Point: 203-206 °C
• Refractive Index: 1.668
• Boiling Point: 518.8 °C at 760 mmHg
• PKA: 6.83±0.40(Predicted)
• Flash Point: 198.3 °C
• PSA: 79.90000
• Density: 1.42 g/cm³
• LogP: 2.87980
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ≥20mg/mL

Purity/Quality:

Wogonin ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Wogonin acts as an anti-inflammatory agent, attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. In addition, it reverses multi-drug resistance of human myelogenous leukemia.

Technology Process of Wogonin

There total 34 articles about Wogonin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

wogonoside methyl ester (82475-01-2) → wogonin (632-85-9)

Guidance literature:

With sulfuric acid; In ethanol; water; at 95 ℃; for 8.5h; Inert atmosphere;

DOI:10.1016/j.tet.2017.02.039

Reference yield: 96.0%

5-hydroxy-8-methoxy-7-methoxymethoxyflavone → wogonin (632-85-9)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 18h;

DOI:10.1080/09168451.2017.1303362

Reference yield: 95.0%

C30H24O5 → wogonin (632-85-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 15 - 25 ℃; Reagent/catalyst;

upstream raw materials:

7-benzyloxy-5-hydroxy-8-methoxy-2-phenyl-4H-chromen-4-one

(E)-3-Phenyl-1-(2,4,6-trihydroxy-3-methoxy-phenyl)-propenone

norwogonin

methyl iodide

Downstream raw materials:

5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl acetate

5,7,8-trimethoxy-2-phenyl-chromen-4-one

norwogonin

5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Refernces

• 1、 Yamashita, Yasunobu,Biard, Alan,Hanaya, Kengo,Shoji, Mitsuru,Sugai, Takeshi. "Short-step syntheses of naturally occurring polyoxygenated aromatics based on site-selective transformation". . p. 1279 - 1284. Retrieved 2017/06/27.
• 2、 -. "Preparation method of flavonoids". . . Retrieved 2017/11/16.