2-Hydroxymethyl Olanzapine

Base Information

• Chemical Name: 2-Hydroxymethyl Olanzapine
• CAS No.: 174756-45-7
• Molecular Formula: C₁₇H₂₀N₄OS
• Molecular Weight: 328.438
• Mol file: 174756-45-7.mol

Synonyms:LY 290411

Chemical Property of 2-Hydroxymethyl Olanzapine

Chemical Property:

• Vapor Pressure: 4.3E-12mmHg at 25°C
• Melting Point: 210-212?C
• Boiling Point: 530.7°C at 760 mmHg
• Flash Point: 274.8°C
• PSA: 79.34000
• Density: 1.4g/cm³
• LogP: 2.07250
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98%Min ^*data from raw suppliers

2-HydroxymethylOlanzapine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A minor metabolite of Olanzapine. A minor metabolite of Olanzapine A minor labelled metabolite of Olanzapine

Technology Process of 2-Hydroxymethyl Olanzapine

There total 7 articles about 2-Hydroxymethyl Olanzapine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-cyanothiophene (4651-82-5) → 2-hydroxymethyl olanzapine (174756-45-7)

Guidance literature:

Multi-step reaction with 5 steps

1: LiOH / dimethylsulfoxide

2: POCl₃

3: SnCl₂, aq. HCl / ethanol

4: NaBH₄ / ethanol

5: toluene; dimethylsulfoxide / Heating

With hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; tin(ll) chloride; trichlorophosphate; In ethanol; dimethyl sulfoxide; toluene;

DOI:10.1016/S0960-894X(96)00567-7

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 2-hydroxymethyl olanzapine (174756-45-7)

Guidance literature:

Multi-step reaction with 5 steps

1: LiOH / dimethylsulfoxide

2: POCl₃

3: SnCl₂, aq. HCl / ethanol

4: NaBH₄ / ethanol

5: toluene; dimethylsulfoxide / Heating

With hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; tin(ll) chloride; trichlorophosphate; In ethanol; dimethyl sulfoxide; toluene;

DOI:10.1016/S0960-894X(96)00567-7

Reference yield:

2-[(2-nitrophenyl)amino]-thiophene-3-carbonitrile (186792-85-8) → 2-hydroxymethyl olanzapine (174756-45-7)

Guidance literature:

Multi-step reaction with 4 steps

1: POCl₃

2: SnCl₂, aq. HCl / ethanol

3: NaBH₄ / ethanol

4: toluene; dimethylsulfoxide / Heating

With hydrogenchloride; sodium tetrahydroborate; tin(ll) chloride; trichlorophosphate; In ethanol; dimethyl sulfoxide; toluene;

DOI:10.1016/S0960-894X(96)00567-7

upstream raw materials:

1-methyl-piperazine

(10-Amino-4H-3-thia-4,9-diaza-benzo[f]azulen-2-yl)-methanol

2-amino-3-cyanothiophene

ortho-nitrofluorobenzene

Refernces

• 1、 Calligaro, David O.,Fairhurst, John,Hotten, Terrence M.,Moore, Nicholas A.,Tupper, David E.. "The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)". . p. 25 - 30. Retrieved 2007/10/03.