2-METHYLIMIDAZO[4,5-C]PYRIDINE

Base Information

• Chemical Name: 2-METHYLIMIDAZO[4,5-C]PYRIDINE
• CAS No.: 63604-59-1
• Molecular Formula: C7H7N3
• Molecular Weight: 133.153
• Hs Code.: 29333990
• Mol file: 63604-59-1.mol

Synonyms:8-Methyl-3-deazapurine;NSC 648928;1H-Imidazo[4,5-c]pyridine, 2-methyl-;3H-Imidazo[4,5-c]pyridine, 2-methyl-;2-Methylimidazo[4,5-c]pyridine;AC1Q4YFD;AC1L861I;

Chemical Property of 2-METHYLIMIDAZO[4,5-C]PYRIDINE

Chemical Property:

• Appearance/Colour: White solid
• Vapor Pressure: 6.86E-06mmHg at 25°C
• Melting Point: 176-178 °C
• Refractive Index: 1.68
• Boiling Point: 388.4 °C at 760 mmHg
• Flash Point: 198.1 °C
• PSA: 41.57000
• Density: 1.273 g/cm³
• LogP: 1.26630
• Storage Temp.: 2-8°C
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

2-Methyl-3H-imidazo[4,5-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Methylimidazo[4,5-c]pyridine is used as a antagonist against platelet-activating factor (PAF).

Technology Process of 2-METHYLIMIDAZO[4,5-C]PYRIDINE

There total 1 articles about 2-METHYLIMIDAZO[4,5-C]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-nitropyridin-4-yl)acetamide (79371-42-9) → 2-methyl-1H-imidazo[4,5-c]pyridine (63604-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / H₂ / 5 percent Pd/C / methanol / 23 h / 20 °C / 5250.42 Torr

2: 97 percent / AcOH / 1.5 h / Heating

With hydrogen; acetic acid; palladium on activated charcoal; In methanol; 1: Hydrogenation / 2: Cyclization;

DOI:10.1002/jhet.5570360505

Reference yield: 81.0%

2-methyl-1H-imidazo[4,5-c]pyridine (63604-59-1) + aniline (62-53-3) → 1H-imidazo[4,5-c]pyridine-2-carbothioic acid phenylamide

Guidance literature:

With sulfur; at 170 - 180 ℃;

Reference yield: 81.0%

formic acid (64-18-6) + 2-methyl-1H-imidazo[4,5-c]pyridine (63604-59-1) + 2,4,6-Trinitrophenol (88-89-1) → picric acid; compound with 2-methyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine-5-carbaldehyde

Guidance literature:

With triethylamine; at 100 ℃; for 10h;

DOI:10.1023/A:1016350629395

upstream raw materials:

N-(3-nitropyridin-4-yl)acetamide

Downstream raw materials:

2-methylimidazo<4,5-c>pyridine 5-oxide

4-(1H-2-methylimidazo[4,5-c]pyrid-1-ylmethyl)aniline

3-(4-cyanophenyl)-2-methylimidazo<4,5-c>pyridine

4-(2-methylimidazo[4,5-c]pyrid-1-yl)benzonitrile

Refernces