glucosilsteviol

Base Information

• Chemical Name: glucosilsteviol
• CAS No.: 60129-60-4
• Molecular Formula: C₂₆H₄₀O₈
• Molecular Weight: 480.599
• Mol file: 60129-60-4.mol

Synonyms:1H-2,10a-Ethanophenanthrene,kaur-16-en-18-oic acid deriv.; Ent-kauran-16-en-19-oic-13-O-b-D-glucoside; Steviolmonoside

Chemical Property of glucosilsteviol

Chemical Property:

• Vapor Pressure: 1.4E-20mmHg at 25°C
• Boiling Point: 666°C at 760 mmHg
• Flash Point: 220.6°C
• PSA: 136.68000
• Density: 1.34g/cm³
• LogP: 1.97920

Purity/Quality:

99% ^*data from raw suppliers

GLUCOSILSTEVIOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of glucosilsteviol

There total 11 articles about glucosilsteviol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

13-O-β-D-glucopyranosyl-19-O-β-D-glucopyranosylsteviol (64849-39-4,104873-42-9) → 13-O-β-glucopyranosol steviol (60129-60-4,64977-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 6.5 percent / acetate buffer (pH: 5.4) / H₂O / 1.) cyclodextrin glucosyltransferase from Bacillus megaterium, 40 deg C, 8 h, 2.) 28 deg C, 10 h; reflux, 15 min

2: 5percent KOH / methanol / 2 h / Heating

With potassium hydroxide; acetate buffer (pH: 5.4); In methanol; water;

Reference yield:

UDP-glucose (133-89-1) + steviol (29584-19-8,471-80-7) → 13-O-β-glucopyranosol steviol (60129-60-4,64977-87-3)

Guidance literature:

With UGT₈₅C₂ SSL S₈₄T mutant enzyme (SEQ ID NO:160); calf intestinal alkaline phosphatase; In aq. buffer; at 37 ℃; for 0.333333h; pH=8; Reagent/catalyst; Enzymatic reaction;

Reference yield:

UDP-glucose (133-89-1) + steviol (29584-19-8,471-80-7) → 13-hydroxy-ent-kaur-16-en-19-oic acid β-D-glucopyranosyl ester (1185737-16-9) + 13-O-β-glucopyranosol steviol (60129-60-4,64977-87-3) + 13-O-β-D-glucopyranosyl-19-O-β-D-glucopyranosylsteviol (64849-39-4,104873-42-9)

Guidance literature:

With glucosyltransferase from Andrographis paniculata; In aq. buffer; at 30 ℃; for 12h; pH=7.4; Enzymatic reaction;

DOI:10.1021/acs.orglett.8b02146

upstream raw materials:

steviol 13-O-β-glucopyranoside 19-β-glucopyranosyl ester

stevioside

13-O-β-D-glucosyl-19-O-β-maltotetrosylsteviol

13-O-β-D-glucosyl-19-O-β-maltopentosylsteviol

Downstream raw materials:

13-O-β-D-glucopyranosyl-19-O-β-D-glucopyranosylsteviol

C₃₂H₅₀O₁₃

steviol 13-O-β-glucopyranoside 19-β-glucopyranosyl ester

C₃₈H₆₀O₁₈

Refernces

• 1、 -. "NATURAL AND SYNTHETIC DITERPENE GLYCOSIDES, COMPOSITIONS AND METHODS". Page/Page column 99; 108-109; 124-125. . Retrieved 2019/08/12.
• 2、 Li, Yuan,Lin, Hui-Xin,Wang, Jian,Yang, Jian,Lai, Chang-Jiang-Sheng,Wang, Xing,Ma, Bao-Wei,Tang, Jin-Fu,Li, Yong,Li, Xin-Lin,Guo, Juan,Gao, Wei,Huang, Lu-Qi. "Glucosyltransferase Capable of Catalyzing the Last Step in Neoandrographolide Biosynthesis". supporting information. p. 5999 - 6002. Retrieved 2018/10/20.