Piperidine-2-carboxamide

Base Information

• Chemical Name: Piperidine-2-carboxamide
• CAS No.: 19889-77-1
• Molecular Formula: C6H12N2O
• Molecular Weight: 128.174
• Hs Code.: 29333990
• European Community (EC) Number: 803-356-2
• DSSTox Substance ID: DTXSID20901505
• Nikkaji Number: J2.361.823K
• Wikidata: Q105328576
• ChEMBL ID: CHEMBL4794008
• Mol file: 19889-77-1.mol

Synonyms:piperidine-2-carboxamide

Chemical Property of Piperidine-2-carboxamide

Chemical Property:

• Vapor Pressure: 0.000553mmHg at 25°C
• Melting Point: 138-140 °C
• Refractive Index: 1.482
• Boiling Point: 311.747 °C at 760 mmHg
• PKA: 16.77±0.20(Predicted)
• Flash Point: 142.34 °C
• PSA: 55.12000
• Density: 1.06 g/cm³
• LogP: 0.64290
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: slightly sol. in Methanol
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 128.094963011
• Heavy Atom Count: 9
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

Piperidine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)C(=O)N

Technology Process of Piperidine-2-carboxamide

There total 30 articles about Piperidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-benzyloxycarbonyl D/L-pipecolinic acid (28697-07-6) → (RS)-piperidine-2-carboxamide (19889-77-1)

Guidance literature:

N-benzyloxycarbonyl D/L-pipecolinic acid; With ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water; for 72h;

With hydrogen; palladium 10% on activated carbon; In methanol; for 20h;

Reference yield: 99.0%

methyl pipecolinate (35677-83-9,41994-45-0,43041-11-8,90710-04-6) → (RS)-piperidine-2-carboxamide (19889-77-1)

Guidance literature:

With ammonia; In methanol; at 90 ℃; for 3h; Sealed tube; Inert atmosphere;

DOI:10.1021/jm3011349

Reference yield: 99.0%

(S)-Piperidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester → (2S)-2-piperidinecarboxamide (19889-77-1,24735-67-9,65057-28-5,78088-51-4)

Guidance literature:

With ammonia; In 1,4-dioxane;

DOI:10.1021/jm0308803

upstream raw materials:

ethyl pipecolate

methyl pipecolinate

piperidine-2-carbonitrile

Tetrahydro-oxazolo[3,4-a]pyridine-1,3-dione

Downstream raw materials:

(5aR,11aS)-7,7-Diphenyl-1,3,4,6,7,11a-hexahydro-2H,5aH-dipyrido[1,2-a;1',2'-c]imidazol-11-one

(5aR,11aR)-7,7-Diphenyl-1,3,4,6,7,11a-hexahydro-2H,5aH-dipyrido[1,2-a;1',2'-c]imidazol-11-one

1-trifluoroacetyl-2-cyanopiperidine

benzyl-[3-tert-butoxycarbonylamino-4-(2-carbamoyl-piperidin-1-yl)-4-oxo-butyl]-carbamic acid tert-butyl ester

Refernces

• 1、 Baranyai, Zsolt,Callegari, Edoardo,Cossi, Maurizio,Fraccarollo, Alberto,Martinelli, Jonathan,Tei, Lorenzo. "Semi-rigid (Aminomethyl) piperidine-based pentadentate ligands for Mn(II) complexation". . . Retrieved 2021/10/12.
• 2、 Ginman, Tobias,Viklund, Jenny,Malmstr?m, Jonas,Blid, Jan,Emond, Rikard,Forsblom, Rickard,Johansson, Anh,Kers, Annika,Lake, Fredrik,Sehgelmeble, Fernando,Sterky, Karin J.,Bergh, Margareta,Lindgren, Anders,Johansson, Patrik,Jeppsson, Fredrik,F?lting, Johanna,Gravenfors, Ylva,Rahm, Fredrik. "Core refinement toward permeable β-secretase (BACE-1) inhibitors with low hERG activity". supporting information. p. 4181 - 4205. Retrieved 2013/07/19.