Benzeneethanol, b-(1,1-dimethylethyl)-, (R)-

Base Information

• Chemical Name: Benzeneethanol, b-(1,1-dimethylethyl)-, (R)-
• CAS No.: 33124-21-9
• Molecular Formula: C12H18O
• Molecular Weight: 178.274
• Mol file: 33124-21-9.mol

Synonyms:

Chemical Property of Benzeneethanol, b-(1,1-dimethylethyl)-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzeneethanol, b-(1,1-dimethylethyl)-, (R)-

There total 18 articles about Benzeneethanol, b-(1,1-dimethylethyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

{(R)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-benzene (217321-19-2) → (R)-3,3-Dimethyl-2-phenyl-1-butanol (33124-21-9)

Guidance literature:

{(R)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-benzene; With ozone; In dichloromethane; at -78 ℃;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 10h; Further stages.;

DOI:10.1021/jo000810t

Reference yield:

(R)-(-)-α-tert-butylphenylacetic acid (13491-16-2) → (R)-3,3-Dimethyl-2-phenyl-1-butanol (33124-21-9)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/jo00829a055

Reference yield:

1H-pyrrole-2-carbonitrile (4513-94-4) + phenyl tert-butyl ketene (57768-77-1) → (R)-3,3-Dimethyl-2-phenyl-1-butanol (33124-21-9) + (S)-3,3-Dimethyl-2-phenyl-1-butanol (54321-15-2)

Guidance literature:

1H-pyrrole-2-carbonitrile; phenyl tert-butyl ketene; (+) planar-chiral PPY derivative Fe; In toluene; at 20 ℃; for 1.5h;

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; Further stages. Title compound not separated from byproducts.;

DOI:10.1021/ja027466x

upstream raw materials:

(R)-(-)-α-tert-butylphenylacetic acid

(S)-(+)-α-tert-butylphenylacetic acid

{(R)-1-[(2S,5R)-2-Isopropyl-5-methyl-cyclohex-(E)-ylidenemethyl]-2,2-dimethyl-propyl}-benzene

(R)-3,3-Dimethyl-2-phenyl-butyric acid 2,2-diphenyl-vinyl ester

Downstream raw materials:

(R)-4,4-dimethyl-3-phenylpentanoic acid

S-(-)-2,2-Dimethyl-3-cyclohexylbutan

(1,2,2-Trimethyl-propyl)-benzene

R-(+)-3,3-Dimethyl-2-phenyl-1-chlorbutan

Refernces

• 1、 Hodous, Brian L,Fu, Gregory C. "Enantioselective addition of amines to ketenes catalyzed by a planar-chiral derivative of PPY: possible intervention of chiral Bronsted-acid catalysis.". . p. 10006 - 10007. Retrieved 2007/10/03.
• 2、 Spino,Beaulieu. "A practical and highly stereoselective umpolung alternative to the alkylation of chiral enolates [19]". . p. 11832 - 11833. Retrieved 2007/10/03.