Technology Process of Benzeneacetic acid, a-(1,1-dimethylethyl)-, (S)-
There total 7 articles about Benzeneacetic acid, a-(1,1-dimethylethyl)-, (S)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium hydroxide monohydrate; dihydrogen peroxide;
In
tetrahydrofuran; water;
at 0 - 2 ℃;
DOI:10.1055/s-0039-1690793
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: zirconium(IV) chloride / dichloromethane / 0.17 h / 23 °C / Inert atmosphere; Glovebox; Sealed tube
1.2: 4 h / 23 °C / Inert atmosphere; Flow reactor; Sealed tube
2.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 0 - 2 °C
With
lithium hydroxide monohydrate; dihydrogen peroxide; zirconium(IV) chloride;
In
tetrahydrofuran; dichloromethane; water;
DOI:10.1055/s-0039-1690793
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 0 - 23 °C / Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
3.1: zirconium(IV) chloride / dichloromethane / 0.17 h / 23 °C / Inert atmosphere; Glovebox; Sealed tube
3.2: 4 h / 23 °C / Inert atmosphere; Flow reactor; Sealed tube
4.1: lithium hydroxide monohydrate; dihydrogen peroxide / tetrahydrofuran; water / 0 - 2 °C
With
n-butyllithium; oxalyl dichloride; lithium hydroxide monohydrate; dihydrogen peroxide; zirconium(IV) chloride;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1055/s-0039-1690793