3,5-dibromo-[1,1'-biphenyl]-4-amine

Base Information

• Chemical Name: 3,5-dibromo-[1,1'-biphenyl]-4-amine
• CAS No.: 3366-59-4
• Molecular Formula: C12H9Br2N
• Molecular Weight: 327.01500
• Hs Code.: 2921499090
• Mol file: 3366-59-4.mol

Synonyms:2,6-dibromo-4-phenylaniline;3.5-Dibrom-4-amino-diphenyl;3,5-dibromo-biphenyl-4-ylamine;3,5-Dibrom-biphenyl-4-ylamin;4-Amino-3,5-dibromobiphenyl;3,5-dibromo-4-aminobiphenyl;

Chemical Property of 3,5-dibromo-[1,1'-biphenyl]-4-amine

Chemical Property:

• Melting Point: 119 °C
• Boiling Point: 351.2±37.0 °C(Predicted)
• PKA: 0.14±0.10(Predicted)
• PSA: 26.02000
• Density: 1.726±0.06 g/cm3(Predicted)
• LogP: 5.04200

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-3,5-dibromobiphenyl is an intermediate in the synthesis of PBB 38 (P215155) which is a brominated biphenyls that can be used as a flame retardant and often incorporated into consumer products including appliances, electronics and plastics.

Technology Process of 3,5-dibromo-[1,1'-biphenyl]-4-amine

There total 8 articles about 3,5-dibromo-[1,1'-biphenyl]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-phenylalanine (92-67-1) → 4-amino-3,5-dibromo-1,1'-biphenyl (3366-59-4)

Guidance literature:

With benzyltrimethylammonium tribromide; calcium carbonate; In methanol; dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo981155g

Reference yield:

con HCl + iridium(III) acetylacetonate + Tridecane (629-50-5) + N-(3,5-dicyclohexyl-4-yl)benzamide + 2,2-dimethoxyethylamine (22483-09-6) → 4-amino-3,5-dibromo-1,1'-biphenyl (3366-59-4)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; In isopropyl alcohol;

Reference yield:

3-bromo-[1,1'-biphenyl]-4-amine (41738-70-9) → 4-amino-3,5-dibromo-1,1'-biphenyl (3366-59-4)

Guidance literature:

With bromine; acetic acid;

upstream raw materials:

3-bromo-[1,1'-biphenyl]-4-amine

4-phenylalanine

bromine

acetic acid

Downstream raw materials:

3,5-dibromo-1,1′-biphenyl

ethyl N-{(3,5-dibromobiphenyl-4-yl)[3,5-bis(trifluoromethyl)biphenyl-4-yl]methyl}carbamate

(3,5-dibromobiphenyl-4-yl)[3,5-bis(trifluoromethyl)biphenyl-4-yl]diazomethane

(3,5-dibromobiphenyl-4-yl)[3,5-bis(trifluoromethyl)biphenyl]chloromethane

Refernces

• 1、 Miura, Yozo,Kurokawa, Shinya,Nakatsuji, Masaaki,Ando, Kenjiro,Teki, Yoshio. "Pyridyl-substituted thioaminyl stable free radicals: Isolation, ESR spectra, and magnetic characterization". . p. 8295 - 8303. Retrieved 2007/10/03.
• 2、 Breeman,Kaspersen,Westra. "Non-specific tritiation of some carcinogenic aromatic amines". . p. 741 - 750,748,749. Retrieved 2007/10/05.