22483-09-6 Usage
Description
2,2-Dimethoxyethylamine is a clear colorless to pale yellow liquid that is formed through a chemical reaction involving aminoacetaldehyde dimethyl acetal with sulfone, followed by hydrolysis and reductive amination by adding a desired piperazine derivative. 2,2-Dimethoxyethylamine is known for its ability to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine, which are important in various chemical and pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
2,2-Dimethoxyethylamine is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its ability to form piperazine derivatives makes it a valuable component in the development of new drugs and therapies.
Used in Chemical Synthesis:
In the chemical industry, 2,2-Dimethoxyethylamine is used as a reagent in the preparation of chitosan-dendrimer hybrids with various functional groups such as carboxyl, ester, and poly(ethylene glycol). These hybrids have potential applications in drug delivery, tissue engineering, and other advanced materials.
Used in Organic Synthesis:
2,2-Dimethoxyethylamine is also utilized in the synthesis of a bicyclic proline analog from L-ascorbic acid, which is an important building block for the development of novel pharmaceuticals and bioactive compounds.
Used in Catalyst Systems:
In the field of catalysis, 2,2-Dimethoxyethylamine is used in a 3-component reaction catalyzed by MgClO4, leading to the formation of α-aminophosphonates. These compounds have potential applications in the development of new drugs and agrochemicals.
Overall, 2,2-Dimethoxyethylamine is a versatile compound with a wide range of applications across different industries, particularly in the pharmaceutical and chemical sectors. Its unique chemical properties and reactivity make it an essential component in the synthesis of various compounds with potential applications in drug development, advanced materials, and catalysis.
Purification Methods
Dry the acetal over KOH pellets and distil it through a 30cm vacuum jacketed Vigreux column (p 11). [Lawson J Am Chem Soc 75 3398 1953, Erickson et al. J Am Chem Soc 77 6640 1955, Beilstein 4 IV 1918.]
Check Digit Verification of cas no
The CAS Registry Mumber 22483-09-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,4,8 and 3 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 22483-09:
(7*2)+(6*2)+(5*4)+(4*8)+(3*3)+(2*0)+(1*9)=96
96 % 10 = 6
So 22483-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H11NO2/c1-6-4(3-5)7-2/h4H,3,5H2,1-2H3/p+1
22483-09-6Relevant articles and documents
Method for preparing aminoacetaldehyde dimethyl acetal
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Paragraph 0047; 0050; 0051; 0054; 0055; 0058, (2020/11/22)
The invention discloses a method for preparing aminoacetaldehyde dimethyl acetal, which comprises the following steps: S1, adding a phase transfer catalyst A and vinyl acetate into a reaction flask, introducing a certain amount of chlorine while stirring, and performing heat-insulation stirring until the color of the reaction solution becomes colorless to obtain a chlorination solution; S2, dropwise adding the chlorination liquid prepared in the step S1 into methanol for reaction to prepare a chloroacetaldehyde dimethyl acetal crude product; S3, transferring the chloroacetaldehyde dimethyl acetal crude product prepared in the step S2 to an autoclave, introducing liquid ammonia, carrying out heating and pressurizing reaction, and after the reaction is finished, adding alkali to adjust the pH value; and S4, decompressing and rectifying the reaction product to obtain the target product, aminoacetaldehyde dimethyl acetal. By adopting the method, high-purity aminoacetaldehyde dimethyl acetal can be prepared, and the industrial production requirement of aminoacetaldehyde dimethyl acetal can be met.
Photorelease of primary aliphatic and aromatic amines by visible-light-induced electron transfer
Edson, Joseph B.,Spencer, Liam P.,Boncella, James M.
supporting information; experimental part, p. 6156 - 6159 (2012/01/05)
Visible-light-absorbing tris(bipyridyl)ruthenium(II) has been used to mediate electron transfer to N-methylpicolinium carbamates that undergo C-O bond fragmentation followed by spontaneous carbon dioxide release to give free amines. Release of several aliphatic and aromatic primary amines has been demonstrated under mild conditions using visible light.
Amine compounds, resist compositions and patterning process
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, (2008/06/13)
Amine compounds having a cyano group are useful in resist compositions for preventing a resist film from thinning and also for enhancing the resolution and focus margin of resist.