344578-07-0

Basic information

• Product Name: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester
• CAS NO: 344578-07-0
• Molecular Weight: 405.385
• Mol File: 344578-07-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester(344578-07-0)
• EPA Substance Registry System: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(2-methoxy-phenyl)-methyl]-phosphonic acid dimethyl ester(344578-07-0)

Safety Data

• Hazardous Substances Data: 344578-07-0(Hazardous Substances Data)

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 135-02-4 ortho-anisaldehyde 
• 22483-09-6 2,2-dimethoxyethylamine 
• 121-45-9 phosphorous acid trimethyl ester 

Downstream Products

• 863290-54-4 1-(3,4-dimethoxy-benzyl)-8-methoxy-isoquinoline 
• 863290-46-4 2-benzoyl-1-cyano-8-methoxy-1,2-dihydroisoquinoline 
• 1723-70-2 8-methoxyisoquinoline 

Relevant articles and documents

Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine

The synthesis and the 125I-apamin binding studies of original C-5- and C-8-substituted 1-(3,4-dimethoxy-benzyl)-2,2-dimethyl-1,2,3,4- tetrahydroisoquinoliniums and 1-(3,4-dimethoxy-benzyl)-6,6-dimethyl-4,5,6,7- tetrahydrothieno[2,3-c]pyridiniums were performed in order to find a reversible and selective SK channel blocker structurally related to N-methyl-laudanosine and N-methyl-noscapine. A bulky alkyl substituent in the C-8 position of the tetrahydroisoquinoline produces a clear increase in the affinity for the apamin sensitive binding sites. The presence of an electron-withdrawing group in the C-5 and C-8 positions is not a suitable substitution for the affinity of drugs structurally related to N-methyl-laudanosine. Thiophenic analogues and 8-methoxy derivatives possess a poor affinity for the apamin sensitive binding sites. Electrophysiological studies performed with the most effective compound showed a blockade of the apamin sensitive afterhyperpolarization in rat dopaminergic neurons.