16 beta,17 beta-epoxy-1,3,5(10)-estratrien-3-ol

Base Information

• Chemical Name: 16 beta,17 beta-epoxy-1,3,5(10)-estratrien-3-ol
• CAS No.: 472-57-1
• Molecular Formula: C18H22 O2
• Molecular Weight: 270.371
• Mol file: 472-57-1.mol

Synonyms:Estra-1,3,5(10)-trien-3-ol,16b,17b-epoxy- (7CI,8CI);16,17-Epoxy-1H-cyclopenta[a]phenanthrene, estra-1,3,5(10)-trien-3-ol deriv.

Chemical Property of 16 beta,17 beta-epoxy-1,3,5(10)-estratrien-3-ol

Chemical Property:

• Vapor Pressure: 4.96E-08mmHg at 25°C
• Boiling Point: 430.9°Cat760mmHg
• Flash Point: 198.2°C
• PSA: 32.76000
• Density: 1.199g/cm³
• LogP: 3.62560

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 16 beta,17 beta-epoxy-1,3,5(10)-estratrien-3-ol

There total 4 articles about 16 beta,17 beta-epoxy-1,3,5(10)-estratrien-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

16α-bromo-3-hydroxy-1,3,5(10)-estratrien-17-one 3-acetate (1239-35-6) → 3-Hydroxyestra-1,3,5(10)-triene 16β,17β-Oxide (472-57-1)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether; Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge;

DOI:10.1021/jo01102a028

Reference yield:

estra-1,3,5(10),16-tetraene-3,17-diol diacetate (20592-42-1) → 3-Hydroxyestra-1,3,5(10)-triene 16β,17β-Oxide (472-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine

2: lithium alanate; diethyl ether / Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge

With lithium aluminium tetrahydride; diethyl ether; bromine;

DOI:10.1021/jo01102a028

Reference yield:

→ 16α,17α-Epoxy-D1.3.5(10)-oestratrienol-(3) (472-56-0,472-57-1)

Guidance literature:

in Lebergeweben;

DOI:10.1016/0006-3002(61)90272-4

upstream raw materials:

16α-bromo-3-hydroxy-1,3,5(10)-estratrien-17-one 3-acetate

16alpha-Bromo-17beta-estradiol

estra-1,3,5⁽¹⁰⁾,16-tetraene-3,17-diol diacetate

Downstream raw materials:

Estriol

16,17-Epiestriol

1,3,5(10)-Estratriene-3,16β-diol

Refernces