cis-4-Hydroxy-3-methylpiperidine

Base Information

• Chemical Name: cis-4-Hydroxy-3-methylpiperidine
• CAS No.: 36173-52-1
• Molecular Formula: C6H13NO
• Molecular Weight: 115.17400
• Mol file: 36173-52-1.mol

Synonyms:cis-4-Hydroxy-3-methylpiperidine;

Chemical Property of cis-4-Hydroxy-3-methylpiperidine

Chemical Property:

• Boiling Point: 191.7±15.0 °C(Predicted)
• PKA: 14.96±0.40(Predicted)
• PSA: 32.26000
• Density: 0.964±0.06 g/cm3(Predicted)
• LogP: 0.30550

Purity/Quality:

NLT 98% ^*data from raw suppliers

rac-(3S,4R)-3-methyl-4-piperidinolhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-4-Hydroxy-3-methylpiperidine

There total 15 articles about cis-4-Hydroxy-3-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(rac)-1-Benzyl-3-methyl-piperidin-4-ol (91600-19-0,790667-50-4) → 4-hydroxy-3-methylpiperidine (33557-57-2,36173-52-1)

Guidance literature:

With hydrogen; palladium on carbon; In tetrahydrofuran; methanol; for 20h; under 2585.81 Torr;

Reference yield: 95.0%

(3,4-trans)-1-benzyl-3-methylpiperidin-4-ol (790667-50-4) → (3,4-trans)-3-methylpiperidin-4-ol (36173-52-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 760.051 Torr;

Reference yield: 87.0%

→ 4-hydroxy-3-methylpiperidine (33557-57-2,36173-52-1)

Guidance literature:

upstream raw materials:

3-methylpiperidine-4-one hydrochloride

ethyl 1-benzoyl-4-oxopiperidine-3-carboxylate

ethyl 1-benzoyl-3-methyl-4-oxo-3-piperidinecarboxylate

(+/-)-trans-1-benzyl-3-methylpiperidin-4-ol

Downstream raw materials:

((2R,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)methanol

2-((2S,4R)-1-(4-(((3,4-trans)-1-(2-fluoro-5-methoxyphenyl)-3-methylpiperidin-4-yl)oxy)phenyl)-4-methoxypyrrolidin-2-yl)acetonitrile

(+/-) tert-butyl trans-4-hydroxy-3-methylpiperidine-1-carboxylate

Refernces

• 1、 -. "SUBSTITUTED BENZOXAZOLES". Paragraph 0527; 0528; 0529; 0530. . Retrieved 2016/06/06.
• 2、 -. "PYRROLIDINE GPR40 MODULATORS". Paragraph 00375. . Retrieved 2014/06/11.