4-methylthiodimethyltryptamine

Base Information

• Chemical Name: 4-methylthiodimethyltryptamine
• CAS No.: 10455-77-3
• Molecular Formula: C₁₃H₁₈N₂S
• Molecular Weight: 234.365
• Hs Code.: 2933990090
• Mol file: 10455-77-3.mol

Synonyms:Indole,3-[2-(dimethylamino)ethyl]-4-(methylthio)- (7CI,8CI);4-Methylthio-N,N-dimethyltryptamine

Chemical Property of 4-methylthiodimethyltryptamine

Chemical Property:

• Vapor Pressure: 1.29E-06mmHg at 25°C
• Boiling Point: 400.3°C at 760 mmHg
• Flash Point: 195.9°C
• PSA: 44.33000
• Density: 1.13g/cm³
• LogP: 2.99390

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methylthiodimethyltryptamine

There total 5 articles about 4-methylthiodimethyltryptamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N,N-Dimethyl-2-(4-methylsulfanyl-1H-indol-3-yl)-2-oxo-acetamide (10419-93-9) → 3-(2-Dimethylaminoethyl)-4-methyl-thioindol (10455-77-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Heating;

DOI:10.1021/jm00350a005

Reference yield:

2-nitro-6-(methylthio)toluene (82173-72-6) → 3-(2-Dimethylaminoethyl)-4-methyl-thioindol (10455-77-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) pyrrolidine, dimethylformamide dimethyl acetal (DMFDA), 2.) Fe, AcOH / 1.) DMF, reflux, 4 h, 2.) EtOH, 85 deg C, 10 min

2: diethyl ether

3: 43 percent / diethyl ether / 0.5 h

4: 68 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

With pyrrolidine; lithium aluminium tetrahydride; iron; acetic acid; N,N-dimethyl-formamide dimethyl acetal; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm00350a005

Reference yield:

4-methylsulfanyl-1H-indole (82173-74-8) → 3-(2-Dimethylaminoethyl)-4-methyl-thioindol (10455-77-3)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: 43 percent / diethyl ether / 0.5 h

3: 68 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether;

DOI:10.1021/jm00350a005

upstream raw materials:

N,N-Dimethyl-2-(4-methylsulfanyl-1H-indol-3-yl)-2-oxo-acetamide

2-nitro-6-(methylthio)toluene

4-methylsulfanyl-1H-indole

Refernces