5-Amino-2-chloropyridine

Base Information

• Chemical Name: 5-Amino-2-chloropyridine
• CAS No.: 5350-93-6
• Molecular Formula: C5H5ClN2
• Molecular Weight: 128.561
• Hs Code.: 29333999
• European Community (EC) Number: 226-322-3
• NSC Number: 81
• UNII: 386QR22KDZ
• DSSTox Substance ID: DTXSID40201716
• Nikkaji Number: J81.013D
• Wikidata: Q72434835
• Mol file: 5350-93-6.mol

Synonyms:5-Amino-2-chloropyridine;5350-93-6;6-chloropyridin-3-amine;2-Chloro-5-aminopyridine;3-Amino-6-chloropyridine;3-Pyridinamine, 6-chloro-;MFCD00006243;2-chloro-5-amino pyridine;6-Chloro-pyridin-3-ylamine;6-Chloro-3-pyridinamine;386QR22KDZ;NSC-81;EINECS 226-322-3;NSC81;5amino-2-chloropyridine;6-chloro-3-aminopyridine;6-chloropyridine-3-amine;6-chloro-pyridin-3-amine;6-chloropyridin-3-ylamine;2-chloro-5-amino-pyridine;3-amino-6-chloro-pyridine;5-amino-2-chloro pyridine;5-amino-2-chloro-pyridine;6-chloro-3-amino pyridine;SCHEMBL9593;6-Chloro-3-pyridinamine #;UNII-386QR22KDZ;Pyridine, 5-amino-2-chloro-;NSC 81;DTXSID40201716;5-Amino-2-chloropyridine, 98%;CHEBI:194601;BCP22171;STR02641;BBL011061;STK802240;AKOS000121100;AB00661;AC-1214;CS-W007481;PS-3660;SY009586;A1155;A7784;AM20061291;FT-0619977;FT-0715296;EN300-34596;AC-907/25014053;Q-103406;F2145-0706;Z335436282

Chemical Property of 5-Amino-2-chloropyridine

Chemical Property:

• Appearance/Colour: light yellow to brown crystalline powder
• Vapor Pressure: 0.00182mmHg at 25°C
• Melting Point: 80-84 °C
• Refractive Index: 1.607
• Boiling Point: 292.6 °C at 760 mmHg
• PKA: 1.94±0.10(Predicted)
• Flash Point: 130.7 °C
• PSA: 38.91000
• Density: 1.326 g/cm³
• LogP: 1.89840
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 128.0141259
• Heavy Atom Count: 8
• Complexity: 76.8

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-6-chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=NC=C1N)Cl
• Uses: 5-Amino-2-chloropyridine was used in the synthesis of [2H5]2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine. It was used in identification and evaluation of molecularly imprinted polymers for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals.

Technology Process of 5-Amino-2-chloropyridine

There total 14 articles about 5-Amino-2-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-chloro-5-nitropyridine (4548-45-2) → 6-Chloro-pyridin-3-ylamine (5350-93-6)

Guidance literature:

With titanium; for 0.25h;

Reference yield: 99.0%

→ 6-Chloro-pyridin-3-ylamine (5350-93-6)

Guidance literature:

In methanol; water; at 20 ℃; for 0.0833333h;

With ammonia borane; In methanol; water; at 20 ℃;

Reference yield: 90.0%

2-choro-5-iodopyridine (69045-79-0) → 6-Chloro-pyridin-3-ylamine (5350-93-6)

Guidance literature:

With copper(l) iodide; ammonia; potassium carbonate; L-proline; In water; dimethyl sulfoxide; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1039/b804637a

upstream raw materials:

6-chloro-3-pyridinecarboxamide

2-chloro-5-nitropyridine

2-chloro-5-fluoropyridine

2-Chloro-5-nitropyridine-1-oxide

Downstream raw materials:

tert-butyl (6-chloropyridin-3-yl)carbamate

N-benzylidene-5-amino-2-chloropyridine

5,5’-diamino-2,2’-bipyridine

5-Amino-2-chloro-N-methylpyridine

Refernces

• 1、 Koohestani, Fatemeh,Sadjadi, Samahe. "Palladated composite of Cu-BDC MOF and perlite as an efficient catalyst for hydrogenation of nitroarenes". . . Retrieved 2021/11/04.
• 2、 Wang, Ming,Jiang, Shikun,Liu, Minrui,Xu, Ling,Narva, Suresh,Awadasseid, Annoor,Wu, Yanling,Zhang, Wen. "Synthesis and anti-cancer activity of naphthopyrone derivatives". supporting information. . Retrieved 2021/05/10.