6-Chloro-N-methylpyridin-3-amine

Base Information

• Chemical Name: 6-Chloro-N-methylpyridin-3-amine
• CAS No.: 120739-84-6
• Molecular Formula: C6H7 Cl N2
• Molecular Weight: 142.588
• Hs Code.: 2933399090
• European Community (EC) Number: 860-659-2
• Nikkaji Number: J1.221.771D
• Mol file: 120739-84-6.mol

Synonyms:6-Chloro-N-methylpyridin-3-amine;120739-84-6;6-CHLORO-N-METHYL-3-PYRIDINAMINE;3-Pyridinamine,6-chloro-N-methyl-(9CI);MFCD10697831;Deoxo-fluoro;3-PYRIDINAMINE, 6-CHLORO-N-METHYL-;(6-Chloro-pyridin-3-yl)-methyl-amine;SCHEMBL758971;2-Chloro-5-methylaminopyridine;6-chloro-3-pyridyl- methylamine;6-chloropyridin-3-yl-methylamine;LFRYVKXHKZPNED-UHFFFAOYSA-N;AMY36951;(6-chloro-pyridin-3-yl)-methylamine;AKOS006305799;AB60605;AS-46752;CS-0376820;EN300-189152;F10385;A856699

Chemical Property of 6-Chloro-N-methylpyridin-3-amine

Chemical Property:

• Vapor Pressure: 0.00503mmHg at 25°C
• Refractive Index: 1.596
• Boiling Point: 275.7°C at 760 mmHg
• Flash Point: 120.5°C
• PSA: 24.92000
• Density: 1.25g/cm³
• LogP: 1.84970
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 142.0297759
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-N-methyl-3-pyridinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=CN=C(C=C1)Cl

Technology Process of 6-Chloro-N-methylpyridin-3-amine

There total 5 articles about 6-Chloro-N-methylpyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(6-chloro-pyridin-3-yl)-formamide (206006-29-3) → 5-Amino-2-chloro-N-methylpyridine (120739-84-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield: 85.0%

methanol (67-56-1) + 2-chloro-5-nitropyridine (4548-45-2) → 5-Amino-2-chloro-N-methylpyridine (120739-84-6)

Guidance literature:

With potassium tert-butylate; C₄₉H₅₀Cl₂Ir₂N₅O⁽¹⁺⁾*F₆P^(1-); at 130 ℃; for 10h;

DOI:10.1021/acs.organomet.0c00464

Reference yield: 67.0%

6-Chloro-pyridin-3-ylamine (5350-93-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-Amino-2-chloro-N-methylpyridine (120739-84-6)

Guidance literature:

With trimethylamine-borane; sodium hydride; at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1039/d0ob01054e

upstream raw materials:

6-Chloro-pyridin-3-ylamine

methyl iodide

N-(6-chloro-pyridin-3-yl)-formamide

N,N-dimethyl-formamide

Downstream raw materials:

(E)-[6-Chloro-3-(methylamino)-2-pyridyl]-3-phenylprop-2-en-1-ol

N₄-(6-chloropyridin-3-yl)-N₂-(3,5-dimorpholinophenyl)-N₄-methylpyrimidine-2,4-diamine

netupitant

2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(o-tolyl)pyridin-3-yl)-N,2-dimethylpropanamide

Refernces

• 1、 Huang, Shuang,Hong, Xi,Cui, He-Zhen,Zhan, Bing,Li, Zhi-Ming,Hou, Xiu-Feng. "Bimetallic Bis-NHC-Ir(III) Complex Bearing 2-Arylbenzo[d]oxazolyl Ligand: Synthesis, Catalysis, and Bimetallic Effects". . p. 3514 - 3523. Retrieved 2020/10/09.
• 2、 -. "COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES". Page/Page column 125; 126. . Retrieved 2014/06/11.