Phenylcyclobutane

Base Information

• Chemical Name: Phenylcyclobutane
• CAS No.: 4392-30-7
• Molecular Formula: C10H12
• Molecular Weight: 132.205
• Hs Code.: 2902909090
• Mol file: 4392-30-7.mol

Synonyms:1-phenylcyclobutane;Benzene,cyclobutyl;1-Phenyl-cyclobutan;Phenylcyclobutane;Cyclobutane,phenyl;cyclobutyl-benzene;Benzene, cyclobutyl-;Cyclobutyl-benzol;

Chemical Property of Phenylcyclobutane

Chemical Property:

• Vapor Pressure: 0.498mmHg at 25°C
• Melting Point: 152 °C(Solv: acetone (67-64-1))
• Refractive Index: 1.5277
• Boiling Point: 198.8°Cat760mmHg
• Flash Point: 65°C
• PSA: 0.00000
• Density: 0.978g/cm³
• LogP: 2.95410

Purity/Quality:

95% ^*data from raw suppliers

Cyclobutylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenylcyclobutane

There total 40 articles about Phenylcyclobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1,4-diiodo-2-phenylbutane (85807-78-9) → phenylcyclobutane (4392-30-7)

Guidance literature:

With tert.-butyl lithium; In diethyl ether; pentane; at -23 ℃; for 0.5h;

DOI:10.1016/S0040-4039(00)85775-5

Reference yield: 31.0%

Bromocyclobutane (4399-47-7) + 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole (24388-23-6) → phenylcyclobutane (4392-30-7)

Guidance literature:

With n-butyllithium; N-Ethylmethylamine; (2,4-bis[(2,6-dimethylphenyl)imino]pentane)iron(III)bis(acetylacetone); methoxybenzene; In benzene; at 25 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.oprd.1c00235

Reference yield: 30.0%

1-phenylcyclobutene (3365-26-2) → phenylcyclobutane (4392-30-7)

Guidance literature:

With ammonia; sodium;

DOI:10.1016/0022-328X(89)88078-7

upstream raw materials:

3-phenyl-1,4,5,6-tetrahydropyridazine

1-(phenyl)cyclobutane-1-carboxylic acid

sodium methylate

2,4-dichloro-3-phenyl-2-cyclobuten-1-one

Downstream raw materials:

1-phenyl-1-cyclobutanol

1-Phenyl-1-butanol

1-methyl-1-phenylethyl alcohol

1-phenylcyclobutene

Refernces

• 1、 Byers, Jeffery A.,Crockett, Michael P.,Li, Bo,Wong, Alexander S.. "Rational Design of an Iron-Based Catalyst for Suzuki–Miyaura Cross-Couplings Involving Heteroaromatic Boronic Esters and Tertiary Alkyl Electrophiles". supporting information. p. 5392 - 5397. Retrieved 2020/03/04.
• 2、 Sawano, Shota,Ishida, Naoki,Murakami, Masahiro. "Hydrogenolysis of 1-alkoxybenzocyclobutenes with site-selective cleavage of the sterically hindered C(sp2)-C(sp3) bond". . p. 1521 - 1523. Retrieved 2015/11/24.