1-Phenylcyclobutane-1-ol

Base Information

• Chemical Name: 1-Phenylcyclobutane-1-ol
• CAS No.: 935-64-8
• Molecular Formula: C10H12O
• Molecular Weight: 148.205
• Hs Code.: 2906299090
• Mol file: 935-64-8.mol

Synonyms:Benzene,cyclobut-1-yl-1-ol;1-phenyl cyclobutanol;1-Phenyl-1-cyclobutanol;Cyclobutanol,1-phenyl;phenylcyclobutanol;

Chemical Property of 1-Phenylcyclobutane-1-ol

Chemical Property:

• Vapor Pressure: 0.00698mmHg at 25°C
• Boiling Point: 258.5°Cat760mmHg
• Flash Point: 94.5°C
• PSA: 20.23000
• Density: 1.134g/cm³
• LogP: 2.05810

Purity/Quality:

99%min ^*data from raw suppliers

1-phenylcyclobutan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenylcyclobutane-1-ol

There total 20 articles about 1-Phenylcyclobutane-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclobutanone (1191-95-3) + phenylmagnesium bromide (100-58-3) → 1-phenyl-1-cyclobutanol (935-64-8)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/adsc.202100329

Reference yield: 91.0%

bromobenzene (108-86-1,52753-63-6) + cyclobutanone (1191-95-3) → 1-phenyl-1-cyclobutanol (935-64-8)

Guidance literature:

bromobenzene; With iodine; magnesium; In tetrahydrofuran; at 40 - 70 ℃; for 2h; Inert atmosphere;

cyclobutanone; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03526

Reference yield: 31.0%

methanol (67-56-1) + propiophenone (495-40-9) → 1-phenyl-1-cyclobutanol (935-64-8) + methyl 1-phenylbutyl ether (81631-43-8) + acetophenone (98-86-2)

Guidance literature:

With triphenylphosphine; for 5h; Product distribution; Kinetics; Mechanism; Irradiation;

DOI:10.1021/jo00165a024

upstream raw materials:

bromobenzene

cyclobutanone

phenylcyclobutane

C₈₀H₉₆O₈*2C₁₀H₁₂O

Downstream raw materials:

phenylcyclobutane

1-phenylcyclobutene

1-chloro-1-phenylcyclobutane

1-fluoro-1-phenylcyclobutane

Refernces

• 1、 Brown. "-". . p. 195. Retrieved 1966.
• 2、 Wu, Shuang,Li, Junzhao,He, Ru,Jia, Kunfang,Chen, Yiyun. "Terminal Trifluoromethylation of Ketones via Selective C-C Cleavage of Cycloalkanols Enabled by Hypervalent Iodine Reagents". supporting information. p. 9204 - 9209. Retrieved 2021/11/30.
• 3、 Hu, Yuanyuan,Luo, Honggen,Tu, Xiangtu,Xue, Han,Jin, Hongwei,Liu, Yunkui,Zhou, Bingwei. "Selective cine -arylation of tert -cyclobutanols with indoles enabled by nickel catalysis". supporting information. p. 4686 - 4689. Retrieved 2021/05/19.