2'-DEOXY-3,4,5,6-TETRAHYDROURIDINE

Base Information

• Chemical Name: 2'-DEOXY-3,4,5,6-TETRAHYDROURIDINE
• CAS No.: 31962-88-6
• Molecular Formula: C₉H₁₆N₂O₅
• Molecular Weight: 232.236
• Mol file: 31962-88-6.mol

Synonyms:2(1H)-Pyrimidinone,1-(2-deoxy-b-D-erythro-pentofuranosyl)tetrahydro-4-hydroxy-(8CI); 2'-Deoxytetrahydrouridine; Tetrahydrodeoxyuridine

Chemical Property of 2'-DEOXY-3,4,5,6-TETRAHYDROURIDINE

Chemical Property:

• Vapor Pressure: 7.55E-18mmHg at 25°C
• Boiling Point: 617.8°Cat760mmHg
• PKA: 12.58±0.40(Predicted)
• Flash Point: 327.4°C
• PSA: 105.75000
• Density: 1.488g/cm³
• LogP: -2.23380

Purity/Quality:

97% ^*data from raw suppliers

2'-DEOXY-3,4,5,6-TETRAHYDROURIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The novel compound 2'-Deoxy-3,4,5,6-tetrahydrouridine is specifically used to inhibit deaminating enzymes, which would inactivate cytosine arabinoside by conversion to uridine arabinoside. Cytosine arabinoside is used for its anti-viral, particularly anti-herpes and anticytotoxic activity in mammals and birds, as well as to destroy phages which interfere with the production of antibiotics.

Technology Process of 2'-DEOXY-3,4,5,6-TETRAHYDROURIDINE

There total 2 articles about 2'-DEOXY-3,4,5,6-TETRAHYDROURIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

Tetrahydrodeoxyuridine (5626-99-3) → 2'-deoxytetrahydrouridine (31962-88-6)

Guidance literature:

With sodium tetrahydroborate; In water; at 0 ℃; for 2h;

DOI:10.1021/jo802599v

Reference yield:

Tetrahydrodeoxyuridine (5626-99-3) → 2'-deoxytetrahydrouridine (31962-88-6) + C9H18N2O5

Guidance literature:

With sodium tetrahydroborate;

DOI:10.1021/jo802599v

upstream raw materials:

Tetrahydrodeoxyuridine

Refernces