5,6-Dihydrodeoxyuridine

Base Information

• Chemical Name: 5,6-Dihydrodeoxyuridine
• CAS No.: 5626-99-3
• Molecular Formula: C9H14 N2 O5
• Molecular Weight: 230.221
• Hs Code.: 2934999090
• UNII: STE2XBS8PY
• Nikkaji Number: J386.844C
• Mol file: 5626-99-3.mol

Synonyms:5,6-Dihydrodeoxyuridine;5626-99-3;5,6-dihydro-2'-deoxyuridine;Dihydrodeoxyuridine;1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinane-2,4-dione;H2dUrd;2'-deoxy-5,6-dihydrouridine;STE2XBS8PY;SCHEMBL658757;2??-Deoxy-5,6-dihydrouridine;Uridine, 2'-deoxy-5,6-dihydro-;MFCD00070301;MFCD10687013;AKOS027326504;NS00070690;Hydrouracil, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-;2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)dihydro-;1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)dihydropyrimidine-2,4(1H,3H)-dione

Chemical Property of 5,6-Dihydrodeoxyuridine

Chemical Property:

• Vapor Pressure: 2.06E-09mmHg at 25°C
• Boiling Point: 481.1°Cat760mmHg
• Flash Point: 244.7°C
• PSA: 99.10000
• Density: 1.31g/cm³
• LogP: -1.33680
• Storage Temp.: −20°C
• Solubility.: Methanol (Slightly), Water (Slightly)
• XLogP3: -1.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 230.09027155
• Heavy Atom Count: 16
• Complexity: 308

Purity/Quality:

98%Min ^*data from raw suppliers

5,6-Dihydro-2''-deoxyuridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CN(C(=O)NC1=O)C2CC(C(O2)CO)O
• Isomeric SMILES: C1CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O
• Uses: 5,6-Dihydro-2''-deoxyuridine is used to screen or binding to a nucleic acid target, such as an RNA or relevant fragment thereof implicated in a disease, disorder, or condition.

Technology Process of 5,6-Dihydrodeoxyuridine

There total 3 articles about 5,6-Dihydrodeoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2'-deoxyuridine (951-78-0,63844-76-8) → Tetrahydrodeoxyuridine (5626-99-3)

Guidance literature:

With hydrogen; Rh/Al₂O₃; In methanol; for 4h; under 1810.02 Torr;

DOI:10.1039/b502302e

Reference yield:

(R)-6-(2,2-Dimethyl-propionyl)-1-((2R,4R,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-dihydro-pyrimidine-2,4-dione → 2'-deoxyuridine (951-78-0,63844-76-8) + Tetrahydrodeoxyuridine (5626-99-3)

Guidance literature:

With 2-hydroxyethanethiol; In methanol; water; for 1.5h; Further Variations:; Reagents; Product distribution; Photolysis;

DOI:10.1021/jo034038g

Reference yield:

→ Tetrahydrodeoxyuridine (5626-99-3)

Guidance literature:

2-Deoxyuridin, H2/Rh;

DOI:10.1021/ja00456a023

upstream raw materials:

2'-deoxyuridine

Downstream raw materials:

5,6-dhydrouracil

C₃₀H₃₂N₂O₇

2'-deoxytetrahydrouridine

Refernces

• 1、 -. "USES OF DIHYDRO BASES". Paragraph 0099. . Retrieved 2014/08/06.
• 2、 Norton, Jolanna,Matsuo, Hiroshi,Sturla, Shana J.. "Synthesis of deoxytetrahydrouridine". experimental part. p. 2221 - 2223. Retrieved 2009/08/07.