5-iodo-8-nitroisoquinoline

Base Information

• Chemical Name: 5-iodo-8-nitroisoquinoline
• CAS No.: 401916-13-0
• Molecular Formula: C9H5IN2O2
• Molecular Weight: 300.05300
• Mol file: 401916-13-0.mol

Synonyms:5-IODO-8-NITROISOQUINOLINE;

Chemical Property of 5-iodo-8-nitroisoquinoline

Chemical Property:

• PSA: 58.71000
• LogP: 3.27080

Purity/Quality:

98.5% ^*data from raw suppliers

5-Iodo-8-nitroisoquinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-iodo-8-nitroisoquinoline

There total 3 articles about 5-iodo-8-nitroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-iodoisoquinoline (58142-99-7) → 5-iodo-8-nitroisoquinoline (401916-13-0)

Guidance literature:

With sulfuric acid; potassium nitrate; at 20 ℃; for 5h;

DOI:10.1021/jm010330+

Reference yield:

isoquinolin-5-ylamine (1125-60-6) → 5-iodo-8-nitroisoquinoline (401916-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: aq. NaNO₂ / H₂O / 0.25 h / 0 °C

1.2: 80 percent / KI / H₂O / 2 h / 100 °C

2.1: 73 percent / KNO₃; H₂SO₄ / 5 h / 20 °C

With sulfuric acid; potassium nitrate; sodium nitrite; In water;

DOI:10.1021/jm010330+

Reference yield:

8-amino quinoline (578-66-5) → 5-iodo-8-nitroisoquinoline (401916-13-0)

Guidance literature:

With hydrogenchloride; sodium chlorite; sodium iodide; In methanol; water; at 20 ℃; for 24h;

DOI:10.1002/chem.201806106

upstream raw materials:

5-iodoisoquinoline

isoquinolin-5-ylamine

8-amino quinoline

Downstream raw materials:

2-(8-isoquinolineamino)-3-nitrobenzoic acid

8-aminoisoquinoline

Refernces

• 1、 Gamage, Swarna A.,Spicer, Julie A.,Rewcastle, Gordon W.,Milton, John,Sohal, Sukhjit,Dangerfield, Wendy,Mistry, Prakash,Vicker, Nigel,Charlton, Peter A.,Denny, William A.. "Structure-activity relationships for pyrido-, imidazo-, pyrazolo-, pyrazino-, and pyrrolophenazinecarboxamides as topoisomerase-targeted anticancer agents". . p. 740 - 743. Retrieved 2007/10/03.