8-Aminoisoquinoline

Base Information

• Chemical Name: 8-Aminoisoquinoline
• CAS No.: 23687-27-6
• Molecular Formula: C9H8N2
• Molecular Weight: 144.176
• Hs Code.: 29334900
• Mol file: 23687-27-6.mol

Synonyms:Isoquinoline,8-amino- (6CI,7CI,8CI);

Chemical Property of 8-Aminoisoquinoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 155-157 °C
• Refractive Index: 1.708
• Boiling Point: 289.8 °C at 760 mmHg
• PKA: 6.20±0.23(Predicted)
• Flash Point: 171.5 °C
• PSA: 38.91000
• Density: 1.21 g/cm³
• LogP: 2.39820
• Storage Temp.: Keep Cold

Purity/Quality:

99% ^*data from raw suppliers

8-Aminoisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Aminoisoquinoline

There total 13 articles about 8-Aminoisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-bromo-8-nitroisoquinoline (63927-23-1) → 8-aminoisoquinoline (23687-27-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol;

DOI:10.1016/j.bmcl.2014.12.086

Reference yield: 99.0%

8-nitroisoquinoline (7473-12-3) → 8-aminoisoquinoline (23687-27-6)

Guidance literature:

With C₂₀H₃₂Cl₄Cu₂N₄O₄; In water; at 60 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.molstruc.2020.128349

Reference yield: 82.0%

5-iodo-8-nitroisoquinoline (401916-13-0) → 8-aminoisoquinoline (23687-27-6)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 3h;

DOI:10.1021/jm010330+

upstream raw materials:

isoquinolin-8-ol

5-chloro-8-nitroisoquinoline

8-nitroisoquinoline

5-iodo-8-nitroisoquinoline

Downstream raw materials:

8-bromo-isoquinoline

2-benzoyl-8-chloro-1-cyano-1,2-dihydroisoquinoline

2-benzoyl-8-bromo-1-cyano-1,2-dihydroisoquinoline

8-bromo-1-(3,4-dimethoxy-benzyl)-isoquinoline

Refernces

• 1、 Du, Jun,Gao, Li-Li,Jia, Wei-Guo,Li, Mei,Zhi, Xue-Ting. "Copper(II) complex with oxazoline ligand: Synthesis, structures and catalytic activity for nitro compounds reduction". . . Retrieved 2020/05/14.
• 2、 -. "PYRROLE ANTIFUNGAL AGENTS". Page/Page column 143. . Retrieved 2009/12/05.