Technology Process of 8-bromo-1-(3,4-dimethoxy-benzyl)-isoquinoline
There total 7 articles about 8-bromo-1-(3,4-dimethoxy-benzyl)-isoquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 86 percent / aluminum chloride / CH2Cl2 / 3 h / 30 °C
2: sodium hydride / dimethylformamide / 4 h / -10 °C
3: aq. NaOH / ethanol / Heating
With
sodium hydroxide; aluminium trichloride; sodium hydride;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049025p
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: NBS; H2SO4 / -25 - -23 °C
2.1: KNO2; H2SO4 / 20 °C
3.1: 53 percent / H2; ammonium acetate / Pd/CaCO3 / methanol / 20 °C / 7500.6 Torr
4.1: NaNO2; HBr / 0 - 5 °C
4.2: 45 percent / CuBr
5.1: 86 percent / aluminum chloride / CH2Cl2 / 3 h / 30 °C
6.1: sodium hydride / dimethylformamide / 4 h / -10 °C
7.1: aq. NaOH / ethanol / Heating
With
ammonium acetate; sodium hydroxide; N-Bromosuccinimide; aluminium trichloride; potassium nitrite; sulfuric acid; hydrogen bromide; hydrogen; sodium hydride; sodium nitrite;
Lindlar's catalyst;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049025p
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: KNO2; H2SO4 / 20 °C
2.1: 53 percent / H2; ammonium acetate / Pd/CaCO3 / methanol / 20 °C / 7500.6 Torr
3.1: NaNO2; HBr / 0 - 5 °C
3.2: 45 percent / CuBr
4.1: 86 percent / aluminum chloride / CH2Cl2 / 3 h / 30 °C
5.1: sodium hydride / dimethylformamide / 4 h / -10 °C
6.1: aq. NaOH / ethanol / Heating
With
ammonium acetate; sodium hydroxide; aluminium trichloride; potassium nitrite; sulfuric acid; hydrogen bromide; hydrogen; sodium hydride; sodium nitrite;
Lindlar's catalyst;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049025p