4-Phenylcyclohexanol

Base Information

• Chemical Name: 4-Phenylcyclohexanol
• CAS No.: 5437-46-7
• Molecular Formula: C₁₂H₁₆O
• Molecular Weight: 176.258
• Hs Code.: 2906299090
• European Community (EC) Number: 227-295-0,230-841-0,226-613-5
• NSC Number: 17139,16118
• DSSTox Substance ID: DTXSID90969470,DTXSID201311111
• Nikkaji Number: J81.032K,J81.090H,J81.372I
• Mol file: 5437-46-7.mol

Synonyms:4-Phenylcyclohexanol;5437-46-7;trans-4-phenylcyclohexanol;4-Phenylcyclohexan-1-ol;5769-13-1;Cyclohexanol, 4-phenyl-;cis-4-Phenylcyclohexan-1-ol;7335-12-8;cis-4-phenylcyclohexanol;trans-4-Phenylcyclohexan-1-ol;4alpha-Phenylcyclohexan-1alpha-ol;(1R,4R)-4-PHENYLCYCLOHEXAN-1-OL;EINECS 226-613-5;EINECS 227-295-0;AI3-12031;NSC17139;4-phenyl-cyclohexanol;4-Phenylcyclohexanol,c&t;4-phenyl-cyclohexan-1-ol;trans-4-phenyl-cyclohexanol;(trans)-4-Phenylcyclohexanol;SCHEMBL557667;Cyclohexanol,4-phenyl-,trans-;(1r,4r)-4-Phenylcyclohexanol;SCHEMBL2778652;SCHEMBL6583115;SCHEMBL22336810;4alpha-Phenylcyclohexan-1beta-ol;DTXSID90969470;DTXSID201311111;(1s,4s)-4-phenylcyclohexan-1-ol;NSC16118;EINECS 230-841-0;MFCD00013757;MFCD31692136;NSC 16118;NSC 17139;NSC-16118;NSC-17139;STK034055;AKOS000249637;AKOS006331415;CCG-356380;LS-14097;CS-0162549;CS-0187050;CS-0375250;FT-0619405;10.14272/YVVUSIMLVPJXMY-HAQNSBGRSA-N;10.14272/YVVUSIMLVPJXMY-TXEJJXNPSA-N;D80500;EN300-116250;EN300-213721;F70178;EN300-6222305;A931455;doi:10.14272/YVVUSIMLVPJXMY-HAQNSBGRSA-N;doi:10.14272/YVVUSIMLVPJXMY-TXEJJXNPSA-N;Z335244834

Chemical Property of 4-Phenylcyclohexanol

Chemical Property:

• Vapor Pressure: 0.000673mmHg at 25°C
• Melting Point: 116-118℃
• Boiling Point: 295.8°Cat760mmHg
• PKA: 15.18±0.40(Predicted)
• Flash Point: 113.3°C
• PSA: 20.23000
• Density: 1.051g/cm³
• LogP: 2.70510
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 176.120115130
• Heavy Atom Count: 13
• Complexity: 141

Purity/Quality:

98% ^*data from raw suppliers

4-Phenylcyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(CCC1C2=CC=CC=C2)O

Technology Process of 4-Phenylcyclohexanol

There total 56 articles about 4-Phenylcyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-phenyl-4-cyclohexanone (4894-75-1) → 4-phenyl-cyclohexanol (5769-13-1,7335-12-8,5437-46-7)

Guidance literature:

With borohydride Ultra resin; In methanol; at 20 ℃; for 16h;

DOI:10.1016/j.tet.2004.05.104

Reference yield: 99.0%

C28H26O3 (1093198-53-8) → trans-4-phenylcyclohexanol (5437-46-7,7335-12-8,5769-13-1)

Guidance literature:

With (triphenylphosphine)gold(I) chloride; silver trifluoromethanesulfonate; In ethanol; benzene; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2008.09.146

Reference yield: 95.0%

trans-2-(4-Phenylcyclohexyloxy)tetrahydropyran (180295-25-4) → trans-4-phenylcyclohexanol (5437-46-7,7335-12-8,5769-13-1)

Guidance literature:

With methanol; scandium tris(trifluoromethanesulfonate); In acetonitrile; at 20 ℃; for 1h;

DOI:10.1081/SCC-100104830

upstream raw materials:

4-Phenylphenol

cis-4-phenylcyclohexanol

acetic acid

1-phenyl-1-cyclohexane

Downstream raw materials:

1-phenyl-4-cyclohexanone

trans-4-phenylcyclohexanol

C₂₈H₂₆O₃

4-Phenylphenol

Refernces

• 1、 -. "Tridentate nitrogen phosphine ligand containing arylamine NH as well as preparation method and application thereof". Paragraph 0121-0122. . Retrieved 2021/06/26.
• 2、 -. "Pincerlike molybdenum complex and preparation method thereof, catalytic composition and application thereof, and alcohol preparation method". Paragraph 0134-0140. . Retrieved 2021/08/11.