1,2-Dimethoxypropane

Base Information

• Chemical Name: 1,2-Dimethoxypropane
• CAS No.: 7778-85-0
• Molecular Formula: C5H12O2
• Molecular Weight: 104.149
• European Community (EC) Number: 404-630-0,626-525-0
• DSSTox Substance ID: DTXSID60871197
• Nikkaji Number: J27.100D
• Mol file: 7778-85-0.mol

Synonyms:1,2-dimethoxypropane

Chemical Property of 1,2-Dimethoxypropane

Chemical Property:

• Vapor Pressure: 40 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.3835(lit.)
• Boiling Point: 96 °C at 760 mmHg
• Flash Point: 0.6 °C
• PSA: 18.46000
• Density: 0.838 g/cm³
• LogP: 0.66770
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 104.083729621
• Heavy Atom Count: 7
• Complexity: 37.1

Purity/Quality:

99% Min. ^*data from raw suppliers

1,2-Dimethoxypropane >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F
• Hazard Codes: F
• Statements: 11-19
• Safety Statements: 9-16-24/25-33

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(COC)OC
• Uses: 1,2-Dimethoxypropane has been used in the preparation of 1,4-dioxanes.

Technology Process of 1,2-Dimethoxypropane

There total 4 articles about 1,2-Dimethoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + methyloxirane (75-56-9,16033-71-9) → 2-hydroxymethylpropyl ether + 2-methoxypropanol (1589-47-5) + 1,2-dimethoxypropane (7778-85-0) + 2,2-dimethoxy-propane (77-76-9)

Guidance literature:

With triphenylsilylcobalt tetracarbonyl; carbon monoxide; boron trifluoride diethyl etherate; at 60 ℃; for 20h; under 45004.5 Torr; Reagent/catalyst;

DOI:10.1016/j.apcata.2021.118291

Reference yield:

methanol (67-56-1) + carbon monoxide (201230-82-2) + methyloxirane (75-56-9,16033-71-9) → 2-hydroxymethylpropyl ether + 3-hydroxybutyric acid methyl ester (1487-49-6) + 2-methoxypropanol (1589-47-5) + 1,2-dimethoxypropane (7778-85-0) + 2,2-dimethoxy-propane (77-76-9)

Guidance literature:

With 3-HYDROXYPYRIDINE; triphenylsilylcobalt tetracarbonyl; at 60 ℃; for 20h; under 45004.5 Torr; Reagent/catalyst; Mechanism;

DOI:10.1016/j.apcata.2021.118291

Reference yield:

sodium methylate (124-41-4) + butyric acid (107-92-6) → 1,2-dimethoxypropane (7778-85-0) + methyl 1-methylethyl carbonate (51729-83-0) + propyl butanoate (105-66-8) + methyl propyl carbonate (56525-42-9)

Guidance literature:

With sodium methyl carbonate; In methanol; for 48h; electrolysis;

DOI:10.1039/P19810002927

upstream raw materials:

sodium methylate

butyric acid

propylene glycol

carbonic acid dimethyl ester

Downstream raw materials:

2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol

methyl 3-fluoropyridine-2-carboxylate

methylene chloride

1,2-Dichloropropane

Refernces

• 1、 -. "CO2-MEDIATED ETHERIFICATION OF BIO-BASED DIOLS". Paragraph 0057; 0058; 0059; 0060. . Retrieved 2016/07/05.