cis-4-tert-butylcyclohexylmethanol

Base Information

• Chemical Name: cis-4-tert-butylcyclohexylmethanol
• CAS No.: 10601-39-5
• Molecular Formula: C₁₁H₂₂O
• Molecular Weight: 170.295
• Mol file: 10601-39-5.mol

Synonyms:Cyclohexanemethanol,4-tert-butyl-, cis- (8CI); cis-4-tert-Butylcyclohexanemethanol;cis-4-tert-Butylcyclohexylmethanol

Chemical Property of cis-4-tert-butylcyclohexylmethanol

Chemical Property:

• Vapor Pressure: 0.0151mmHg at 25°C
• Boiling Point: 227.5°Cat760mmHg
• Flash Point: 97.8°C
• PSA: 20.23000
• Density: 0.89g/cm³
• LogP: 2.83120

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cis-4-tert-butylcyclohexylmethanol

There total 53 articles about cis-4-tert-butylcyclohexylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cis-4-t-butylcyclohexanecarboxylic acid (943-28-2) → cis-(4-tert-butylcyclohexyl)methanol (13004-06-3,20691-53-6,10601-39-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja301685r

Reference yield: 60.0%

(3r,6r)-6-(tert-butyl)-1-oxaspiro[2.5]octane (18881-26-0) → cis-(4-tert-butylcyclohexyl)methanol (13004-06-3,20691-53-6,10601-39-5) + trans-(4-tert-butyl-cyclohexyl)-methanol (10601-39-5,20691-53-6,13004-06-3) + trans-4-(tert-butyl)cyclohexane-1-carbaldehyde (15763-62-9) + t-butyl-4 cyclohexanecarboxaldehyde cis (15763-61-8)

Guidance literature:

With hydrogen; Rh on carbon; In cyclohexane; at 20 ℃; under 760 Torr; Further byproducts given;

Reference yield: 60.0%

(3r,6r)-6-(tert-butyl)-1-oxaspiro[2.5]octane (18881-26-0) → cis-(4-tert-butylcyclohexyl)methanol (13004-06-3,20691-53-6,10601-39-5) + trans-(4-tert-butyl-cyclohexyl)-methanol (10601-39-5,20691-53-6,13004-06-3) + trans-4-(tert-butyl)cyclohexane-1-carbaldehyde (15763-62-9) + t-butyl-4 cyclohexanecarboxaldehyde cis (15763-61-8)

Guidance literature:

With hydrogen; Rh on carbon; In cyclohexane; at 20 ℃; under 760 Torr; Further byproducts given;

upstream raw materials:

cis-4-t-butylcyclohexanecarboxylic acid

6-tert-Butyl-1-oxa-spiro[2.5]octane

(3r,6r)-6-(tert-butyl)-1-oxaspiro[2.5]octane

4-(tert-butyl)cyclohexylmethyl acetate

Downstream raw materials:

methyl esters of cis-4-tert-butylcyclohexanecarboxylic acid

t-butyl-4 cyclohexanecarboxaldehyde cis

trans-4-t-butylcyclohexylmethyl bromide

trans-4-(tert-butyl)cyclohexane-1-carbaldehyde

Refernces

• 1、 Hiroya,Hasegawa,Watanabe,Ogasawara. "Lipase-mediated kinetic separation of a diastereomeric mixture of 4-tert-butylcyclohexanemethanol". . p. 379 - 381. Retrieved 1995.
• 2、 Crouch, R. David,Mitten, Jeffrey V.,Span, Amelia R.,Dai, H. George. "A mild, convenient, Non-Acidic conversion of enol ethers into alcohols using Hg(OAc)2 - NaBH4". . p. 791 - 794. Retrieved 1997.
• 3、 Mori. "-". . p. 1567. Retrieved 1961.
• 4、 Zhang, Yong-Qiang,Jakoby, Verena,Stainer, Katharina,Schmer, Alexander,Klare, Sven,Bauer, Mirko,Grimme, Stefan,Cuerva, Juan Manuel,Gans?uer, Andreas. "Amide-Substituted Titanocenes in Hydrogen-Atom Transfer Catalysis". supporting information. p. 1523 - 1526. Retrieved 2016/02/12.
• 5、 Jimenez, Tania,Campana, Araceli G.,Bazdi, Btissam,Paradas, Miguel,Arraez-Roman, David,Segura-Carretero, Antonio,Fernandez-Gutierrez, Alberto,Oltra, J. Enrique,Robles, Rafael,Justicia, Jose,Cuerva, Juan M.. "Radical reduction of epoxides using a titanocene(III)/water system: Synthesis of β-deuterated alcohols and their use as internal standards in food analysis". experimental part. p. 4288 - 4295. Retrieved 2010/10/21.