1-Methyl-4-phenylpiperidine-4-carbonitrile

Base Information Edit

Chemical Name:1-Methyl-4-phenylpiperidine-4-carbonitrile
CAS No.:3627-62-1
Molecular Formula:C13H16N2
Molecular Weight:200.283
Hs Code.:2933399090
European Community (EC) Number:222-847-7
NSC Number:28344
UNII:EL4L2474TY
DSSTox Substance ID:DTXSID50189814
Nikkaji Number:J28.012G
Wikipedia:Pethidine_intermediate_A
Wikidata:Q7178319
ChEMBL ID:CHEMBL495954
Mol file:3627-62-1.mol

Synonyms:1-Methyl-4-phenylpiperidine-4-carbonitrile;3627-62-1;4-Piperidinecarbonitrile, 1-methyl-4-phenyl-;4-Cyano-1-methyl-4-phenylpiperidine;UNII-EL4L2474TY;1-Methyl-4-phenyl-4-piperidinecarbonitrile;CHEMBL495954;EL4L2474TY;EINECS 222-847-7;NSC-28344;1-Methyl-4-phenyl-4-piperidine carbonitrile;Prepethidine;NSC28344;1-Methyl-4-phenyl-piperidine-4-carbonitrile;Pethidine - Intermediate-A;SCHEMBL504355;PETHIDINE INTERMEDIATE A;IDS-NP-002;DEA No. 9232;DTXSID50189814;HMS1697N02;BDBM50265405;NSC 28344;STK664584;AKOS000643483;NCGC00160427-01;1-METHYL-4-PHENYLISONIPECOTONITRILE;1-METHYL-4-CYANO-4-PHENYLPIPERIDINE;4-CYANO-1-METHYL-4-PHENYLPIPERIDINE-;ISONIPECOTONITRILE, 1-METHYL-4-PHENYL-;Q7178319;PETHIDINE-INTERMEDIATE-A, 4-CYANO-1-METHYL-4-PHENYLPIPERIDINE

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Chemical Property of 1-Methyl-4-phenylpiperidine-4-carbonitrile Edit

Chemical Property:

Vapor Pressure:0.000145mmHg at 25°C
Refractive Index:1.565
Boiling Point:332.5 °C at 760 mmHg
Flash Point:141 °C
PSA：27.03000
Density:1.07 g/cm³
LogP:2.11148
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:200.131348519
Heavy Atom Count:15
Complexity:249

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CCC(CC1)(C#N)C2=CC=CC=C2

Technology Process of 1-Methyl-4-phenylpiperidine-4-carbonitrile

There total 17 articles about 1-Methyl-4-phenylpiperidine-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3627-62-1
1-methyl-4-phenyl-piperidine-4-carbonitrile

Guidance literature:

Reference yield: 75.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 40481-13-8
4-phenyl-4-cyanopiperidine

: 3627-62-1
1-methyl-4-phenyl-piperidine-4-carbonitrile

Guidance literature:: formaldehyd; 4-phenyl-4-cyanopiperidine; With acetic acid; In tetrahydrofuran; water; at 20 ℃; for 0.5h;

With water; sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h;