4-PHENYL-PIPERIDINE-4-CARBONITRILE

Base Information

• Chemical Name: 4-PHENYL-PIPERIDINE-4-CARBONITRILE
• CAS No.: 40481-13-8
• Molecular Formula: C12H14 N2
• Molecular Weight: 186.257
• Hs Code.: 2933399090
• Mol file: 40481-13-8.mol

Synonyms:4-Cyano-4-phenylpiperidine;4-Phenyl-4-cyanopiperidine; 4-Phenyl-4-piperidinecarbonitrile

Chemical Property of 4-PHENYL-PIPERIDINE-4-CARBONITRILE

Chemical Property:

• Boiling Point: 145-146 °C(Press: 2 Torr)
• PKA: 9.01±0.10(Predicted)
• PSA: 35.82000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 2.16018

Purity/Quality:

99% ^*data from raw suppliers

4-Phenylpiperidine-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-PHENYL-PIPERIDINE-4-CARBONITRILE

There total 7 articles about 4-PHENYL-PIPERIDINE-4-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-benzyl-4-cyano-4-phenylpiperidine (56243-25-5) → 4-phenyl-4-cyanopiperidine (40481-13-8)

Guidance literature:

With palladium on carbon; hydrogen; In ethanol;

DOI:10.1016/j.bmcl.2010.08.047

Reference yield:

phenylacetonitrile (140-29-4) + N,N-bis(chloro-2-ethyl)amine (334-22-5) → 4-phenyl-4-cyanopiperidine (40481-13-8)

Guidance literature:

With sodium amide; toluene;

DOI:10.1021/ja01203a005

Reference yield:

4-cyano-4-phenylpiperidine hydrochloride (51304-58-6) → 4-phenyl-4-cyanopiperidine (40481-13-8)

Guidance literature:

With sodium hydroxide; In water;

upstream raw materials:

phenylacetonitrile

N,N-bis(chloro-2-ethyl)amine

tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate

4-cyano-4-phenylpiperidine hydrochloride

Downstream raw materials:

(4-phenylpiperidin-4-yl)methanamine

1,3-Diacetyl-2-hydroxy-6-methyl-4-(4-cyano-4-phenyl-piperidino)-benzol

4-Cyano-1-(4-phenylbutyl)-4-phenylpiperidin

1-(3-Chloro-8-methyl-4-o-tolylamino-quinolin-2-ylmethyl)-4-phenyl-piperidine-4-carbonitrile

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF". Paragraph 0339; 0341. . Retrieved 2013/05/09.
• 2、 Tang, Haifeng,Yan, Yan,Feng, Zhe,De Jesus, Reynalda K.,Yang, Lihu,Levorse, Dorothy A.,Owens, Karen A.,Akiyama, Taro E.,Bergeron, Raynald,Castriota, Gino A.,Doebber, Thomas W.,Ellsworth, Kenneth P.,Lassman, Michael E.,Li, Cai,Wu, Margaret S.,Zhang, Bei B.,Chapman, Kevin T.,Mills, Sander G.,Berger, Joel P.,Pasternak, Alexander. "Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities". scheme or table. p. 6088 - 6092. Retrieved 2010/11/18.