56243-25-5

Basic information

• Product Name: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride
• Synonyms: 1-BENZYL-4-CYANO-4-PHENYLPIPERIDINE;4-PIPERIDINECARBONITRILE, 4-PHENYL-1-(PHENYLMETHYL)-;4-PHENYL-1-(PHENYLMETHYL)-4-PIPERIDINECARBONITRILE;1-Benzyl 4-Cyano Phenyl Piperidine Hcl;1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride 99%;1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride;4-Phenyl-1-(phenylmethyl)-4-piperidinecarbonitrile hydrochloride;N-BENZYL-4-CYANO-4-PHENYL PIPERIDINE
• CAS NO: 56243-25-5
• Molecular Formula: C₁₉H₂₀N₂
• Molecular Weight: 312.84
• EINECS: 275-305-7
• Product Categories: Piperidines, Piperidones, Piperazines;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 56243-25-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 250-259°C
• Boiling Point: 430.4oC at 760mmHg
• Flash Point: 184.3oC
• Appearance: /
• Density: 1.12g/cm3
• Vapor Pressure: 1.3E-07mmHg at 25°C
• CAS DataBase Reference: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride(56243-25-5)
• EPA Substance Registry System: 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride(56243-25-5)

Safety Data

• Hazard Codes: Xn:有害物质‖Xi
• Statements: 20/21/22
• Safety Statements: 22-36/37/39
• Hazardous Substances Data: 56243-25-5(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Crystalline Solid

Uses

A piperidine derivative as calcium channel blockers

InChI:InChI=1/C19H20N2/c20-16-19(18-9-5-2-6-10-18)11-13-21(14-12-19)15-17-7-3-1-4-8-17/h1-10H,11-15H2/p+1

Upstream product

• 55-51-6 N,N-bis(2-chloro-ethyl)-benzenemethanamine 
• 140-29-4 phenylacetonitrile 
• 100119-73-1 1,5-dichloro-3-cyano-3-phenylpentane 
• 100-46-9 benzylamine 
• 40481-13-8 4-phenyl-4-cyanopiperidine 
• 10469-27-9 α,α-bis(2-hydroxyethyl)phenylacetonitrile 
• 101-32-6 N-benzyl-diethanolamine 
• 100-39-0 benzyl bromide 
• 51304-58-6 4-cyano-4-phenylpiperidine hydrochloride 
• 75-21-8 oxirane 

Downstream Products

• 94909-20-3 1-(1-benzyl-4-phenyl-[4]piperidyl)-propan-1-one 
• 84176-77-2 1-Benzyl-4-phenylpiperidin-4-yl-methanamin 
• 102552-22-7 1-(1-benzyl-4-phenyl-[4]piperidyl)-ethanone-imine 
• 84176-76-1 1-benzyl-4-phenyl-piperidine-4-carboxylic acid amide 
• 61886-17-7 1-benzyl-4-phenyl-piperidine-4-carboxylic acid 
• 199439-86-6 1-Benzyl-1-oxy-4-phenyl-piperidine-4-carboxylic acid amide 
• 26979-21-5 1-benzyl-4-phenyl-piperidine-4-carbaldehyde 
• 59084-08-1 1-benzyl-4-phenyl-piperidine-4-carboxylic acid ethyl ester 
• 1013330-27-2 1-benzyl-4-phenylpiperidine-4-carboxylic acid hydrochloride 
• 538324-30-0 3-[4-(4-bromo-phenyl)-piperidin-4-yl]-propionic acid methyl ester 
• 904283-17-6 3-(1-benzyl-4-phenyl-piperidin-4-yl)-propionic acid methyl ester 
• 538324-33-3 4-(4-bromo-phenyl)-4-(2-methoxycarbonyl-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 538324-34-4 4-(4-bromo-phenyl)-4-[2-(3,4-difluoro-phenylcarbamoyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 538323-78-3 4-(3'-cyano-biphenyl-4-yl)-4-[2-(3,4-difluoro-phenylcarbamoyl)-ethyl]-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

A 4-substituted piperidine derivatives synthetic method

The invention relates to a synthesis method of 4-substituted piperidine derivatives. The synthesis method comprises the following steps: continuously reacting alpha-single substituted acetonitrile serving as a raw material with two-molecular ethylene oxide in the presence of a base I, thereby synthesizing compounds (2), wherein not one compound (2) is generated, and the compounds (2) are in tautomeric equilibrium with a compound (6); breaking the balance in the presence of a base II to generate an alcoxyl negative ion compound (3); reacting the compound (3) with R2SO2X or (R2SO2)2O to generate sulphonates (4); performing a cyclization reaction on the sulphonates (4) and primary amine to synthesize 4-substituted piperidine derivatives. Compared with a document reported method, the synthesis method has the advantages that the reaction steps are shortened and the synthetic efficiency is improved.

Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands

A series of N-substituted-4-cyano-4-phenylpiperidine analogs were synthesized and evaluated for binding affinity at opioid receptors and showed no affinity. The series similarity to previously reported σ ligands prompted analysis at σ receptors to determine the SAR for affinity at σ receptors. Within the N-substituent series the saturated analogs showed increased affinity at both σ receptors. Optimal chain length in the N-arylalkyl series for σ1 and σ2 receptors proved to be N-propylphenyl; extension to a four carbon chain dramatically decreased affinity at both receptors. Substituents in the 4-position affect only σ1 affinity; no change in affinity at σ2 was shown. The N-isobutyl, N-phenylpropyl, and N-benzyl analogs are worth pursuing due to their good affinity and selectivity at the σ1 receptor, whereas the N-benzyl analog exhibits the greatest selectivity for σ1.

DIARYL PIPERIDINE COMPOUNDS AS CALCIUM CHANNEL BLOCKERS

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