1-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-propanone

Base Information

• Chemical Name: 1-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-propanone
• CAS No.: 4899-74-5
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Mol file: 4899-74-5.mol

Synonyms:

Chemical Property of 1-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-propanone

Chemical Property:

• PSA: 66.76000
• LogP: 0.50470

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-propanone

There total 10 articles about 1-Hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

guaiacylglycerol-β-guaiacyl ether (7382-59-4) → 2-propanone,1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)- (4899-74-5) + 2-methoxy-phenol (90-05-1)

Guidance literature:

With methylimidazolium bromide; at 110 ℃; for 0.0833333h; Sealed tube; Inert atmosphere; Green chemistry;

DOI:10.1002/cssc.201701668

Reference yield: 68.0%

1-(4-((tert-butyldimethylsilyl)oxy)-3-methoxyphenyl)propane-1,2,3-triol → 2-propanone,1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)- (4899-74-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; for 0.5h; Reflux; Inert atmosphere;

DOI:10.1039/c6ob01915c

Reference yield:

formic acid (64-18-6) + guaiacylglycerol-β-guaiacyl ether (7382-59-4) → 2-propanone,1-hydroxy-3-(4-hydroxy-3-methoxyphenyl)- (4899-74-5) + 2,4'-dihydroxy-3'-methoxyacetophenone (18256-48-9) + 3-(4-hydroxy-3-methoxyphenyl)-2-(2-methoxy-phenoxy)-2-propenol (58046-03-0) + C18H18O6 + vanillin (121-33-5,8014-42-4) + 2-methoxy-phenol (90-05-1) + α-hydroxy-4-hydroxy-3-methoxybenzeneacetic acid methyl ester (2911-74-2,108100-20-5)

Guidance literature:

In water; at 130 ℃; for 0.1h; Mechanism;

DOI:10.1039/c9gc02315a

upstream raw materials:

2-(4-acetoxy-3-methoxyphenyl)acetic acid

threo-guaiacylglycerol

Homovanillic acid

(4-acetoxy-3-methoxy-phenyl)-acetonitrile

Downstream raw materials:

1-acetoxy-3-(4-acetoxy-3-methoxy-phenyl)-acetone

1-(3-Methoxy-4-trimethylsilanyloxy-phenyl)-3-trimethylsilanyloxy-propan-2-one

Refernces

• 1、 Thierry, Marina,Majira, Amel,Pégot, Bruce,Cezard, Laurent,Bourdreux, Flavien,Clément, Gilles,Perreau, Fran?ois,Boutet-Mercey, Stéphanie,Diter, Patrick,Vo-Thanh, Giang,Lapierre, Catherine,Ducrot, Paul-Henri,Magnier, Emmanuel,Baumberger, Stéphanie,Cottyn, Betty. "Imidazolium-Based Ionic Liquids as Efficient Reagents for the C?O Bond Cleavage of Lignin". . p. 439 - 448. Retrieved 2018/02/06.
• 2、 Zhu, Chenjie,Ding, Weiwei,Shen, Tao,Tang, Chenglun,Sun, Chenguo,Xu, Shichao,Chen, Yong,Wu, Jinglan,Ying, Hanjie. "Metallo-deuteroporphyrin as a biomimetic catalyst for the catalytic oxidation of lignin to aromatics". . p. 1768 - 1778. Retrieved 2015/06/08.