methylketene

Base Information

• Chemical Name: methylketene
• CAS No.: 6004-44-0
• Molecular Formula: C3H4 O
• Molecular Weight: 56.0642
• Hs Code.: 2914190090
• Mol file: 6004-44-0.mol

Synonyms:Ketene,methyl- (6CI,7CI,8CI); Methylketene

Chemical Property of methylketene

Chemical Property:

• Vapor Pressure: 2.31E-06mmHg at 25°C
• Refractive Index: 1.3810 (estimate)
• Boiling Point: 392.3°C at 760 mmHg
• Flash Point: 191.1°C
• PSA: 17.07000
• Density: 1.256g/cm³
• LogP: 0.39410

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methylketene

There total 40 articles about methylketene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

α-bromopropionyl bromide (563-76-8) → prop-1-en-1-one (6004-44-0)

Guidance literature:

With zinc; In diethyl ether; at 20 ℃; Solvent;

DOI:10.1055/s-0034-1380679

Reference yield: 90.0%

2-Bromopropionyl chloride (7148-74-5) → prop-1-en-1-one (6004-44-0)

Guidance literature:

With {bis(triphenylphosphine)nitrogen}{manganese(carbonyl)5}; In chloroform; at 0 ℃; for 3h; under 0.1 - 20 Torr;

DOI:10.1021/jo00368a036

Reference yield: 80.0%

{Co2(μ-CHCH3)2(CO)4(μ-dppm)} → Co2(CO)4(μ-CO)2(μ-bis(diphenylphosphino)methane) (52615-19-7) + prop-1-en-1-one (6004-44-0)

Guidance literature:

With carbon monoxide; In neat (no solvent); pyrolysis under CO atmosphere at 25°C;; not isolated; detected by NMR spectroscopy; ketene trapped by reaction with CD3OD with formation of the corresponding ester;;

upstream raw materials:

α-bromopropionyl bromide

diazoacetone

phenyl propionate

propionic acid

Downstream raw materials:

p-tolyl propionate

Ketene

ethane-1,1-diyl

2,4-dimethyl-cyclobutane-1,3-dione

Refernces

• 1、 Mondal, Mukulesh,Wheeler, Kraig A.,Kerrigan, Nessan J.. "Alkaloid-Catalyzed Enantioselective [3 + 2] Cycloaddition of Ketenes and Azomethine Imines". . p. 4108 - 4111. Retrieved 2016.
• 2、 Hafner, Andreas,Ley, Steven V.. "Generation of Reactive Ketenes under Flow Conditions through Zinc-Mediated Dehalogenation". supporting information. p. 1470 - 1474. Retrieved 2015/06/30.